Abstract
An enzyme-linked immunoassay was used to determine serum content of IgG and IgM antibodies against eight capsular polysaccharides ofStreptococcus pneumoniae in 19 patients with chronic obstructive lung dieseases 3 years after inoculation with a polyvalent pneumococcal vaccine (Moniatrix); 21 unvaccinated patients with comparable diseases served as the control group. The vaccinated group showed slightly more pronounced IgG antibody reactions than the unvaccinated group, but the differences were not statistically significant. These results show that pneumococcal vaccination does not provide long-term protection at least for patients with chronic obstructive lung disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Austrian R (1980) The assessment of pneumococcal vaccine. N Engl J Med 303:578–580
Austrian R, Gold J (1964) Pneumococcal bacteremia with special reference to bacteremic pneumococcal pneumonia. Ann Intern Med 60:759–776
Berntsson E, Broholm KA, Kayser B (1978) Serological diagnosis of pneumococcal disease with enzyme-linked immunosorbent assay (ELISA). Scand J Infect Dis 10:177–181
Broome CV, Facklam RR, Fraser DW (1980) Pneumococcal disease after pneumococcal vaccination. N Engl. J Med 303:549–552
Centers for Disease Control (1978) Recommendation: pneumococcal polysaccharid vaccine. Morbidity Mortality Weekly Rep 27:25–34
Engvall E, Perlmann P (1972) Enzyme-linked immunosorbent assay, ELISA. III. Quantitation of specific antibodies by enzyme-labeled anti-immunoglobulin in antigen-coated tubes. J Immunol 109:129–135
Mac Leod CM, Hodges RG, Heidelberger M, Bernhard WG (1945) Prevention of pneumococcal pneumonia by immunisation with specific capsular polysaccharides. J Exp Med 82:445–465
Mufson MA, Krause HE, Schiffmann G (1983) Long-term persistence of antibody following immunisation with pneumococcal polysaccharide vaccine. Proc Soc Exp Biol Med 173:270–275
Newhouse M, Sanchis J, Bienenstock J (1976) Lung defense mechanisms (second of two parts). N Engl J Med 295:1045–1052
Pucci M, Clanchy R, Jackson G (1982) Quantitation of T-lymphocyte subsets in human bronchus mucosa. Am Rev Respir Dis 126:364–366
Schiffman G, Douglas RM, Bonner MJ, Robbins M, Austrian R (1980) A radioimmunoassay for immunologic phenomena in pneumococcal disease and for the antibody response to pneumococcal vaccines. I. Method for the radioimmunoassay of anticapsular antibodies and comparison with other techniques. J Immunol Methods 33:133–144
Vella PP, McLean AA, Woodhour AF, Weibel RE, Hillmann MR (1980) Persistence of pneumococcal antibodies in human subjects following vaccination. Proc Soc Exp Biol Med 164:435–438
Weibel RE, Vella PP, McLean AA, Woodhour AF, Davidson WL, Hillmann MR (1977) Studies in human subjects of polyvalent pneumococcal vaccines. Proc Soc Exp Biol Med 156:144–150
Wright AE, Parry Morgan W, Colebrook L, Dodgson RW (1914) Observations on prophylactic inoculation against pneumococcus infections, and the results achieved by it. Lancet I:1–10
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kraus, C., Fischer, S., Ansorg, R. et al. Pneumococcal antibodies (IgG, IgM) in patients with chronic obstructive lung disease 3 years after pneumococcal vaccination. Med Microbiol Immunol 174, 51–58 (1985). https://doi.org/10.1007/BF02123671
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF02123671