Abstract
Abstract In the present study we examined the effects of intermittent (IH) and sustained hypoxia (SH) on low PO2-evoked catecholamine (CA) secretion from neonatal rat chromaffin cells. Experiments were performed on chromaffin cells isolated from rat pups exposed to either IH (P0–P5; 15 s hypoxia-5 min normoxia;8 h/day) or SH (hypobaric hypoxia; 0.4ATM). CA secretion from chromaffin cells was monitored by amperometry. Control chromaffin cells, from P5 rat pups, exhibited robust CA secretion in response to acute hypoxia. IH facilitated whereas SH attenuated hypoxia-evoked CA secretion. IH increased the epinephrine and norepinephrine content of the adrenal medulla whereas SH had no effect. These results demonstrate that neonatal exposures IH and SH exert diametrically opposed effects on acute hypoxia-evoked CA secretion from chromaffin cells and CA contents.
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Souvannakitti, D., Kumar, G.K., Fox, A., Prabhakar, N.R. (2009). Contrasting Effects of Intermittent and Continuous Hypoxia on Low O2 Evoked Catecholamine Secretion from Neonatal Rat Chromaffin Cells. In: Gonzalez, C., Nurse, C.A., Peers, C. (eds) Arterial Chemoreceptors. Advances in Experimental Medicine and Biology, vol 648. Springer, Dordrecht. https://doi.org/10.1007/978-90-481-2259-2_39
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DOI: https://doi.org/10.1007/978-90-481-2259-2_39
Publisher Name: Springer, Dordrecht
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