Brief ReviewNonenzymatic Nitric Oxide Production in Humans☆
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Cited by (233)
Ascorbate mediates the non-enzymatic reduction of nitrite to nitric oxide
2023, Advances in Redox ResearchNitric oxide resistance in type 2 diabetes: Potential implications of HNO donors
2023, Nitric Oxide in Health and Disease: Therapeutic Applications in Cancer and Inflammatory DisordersNitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes
2022, Nitric Oxide - Biology and ChemistryCitation Excerpt :In addition, a more rapid pathway for nitrate reduction has been identified in which circulating nitrate (whether from dietary sources or NO oxidation) is actively transported into the mouth via the protein sialin [54], where it is reduced by commensal, facultative bacteria into nitrite [55]. The nitrite is then swallowed and a portion undergoes acidic reduction into NO and other nitrogen oxides in the stomach [51,52]. Some of the nitrite also reaches systemic circulation, where it can be transported to various tissue throughout the body and further reduced to NO via nitrite reductases [52].
The crucial role of non-enzymatic NO-production in plants. An EPR study
2021, PhytochemistryS-nitrosothiols, and other products of nitrate metabolism, are increased in multiple human blood compartments following ingestion of beetroot juice
2021, Redox BiologyCitation Excerpt :In the NO3⁻ - NO2⁻ - NO pathway, NO3⁻ is rapidly reduced to NO2⁻ in the mouth by obligate and facultative anaerobic bacteria, resulting in a high salivary NO2⁻ concentration. Once swallowed, NO2⁻ in the stomach is exposed to a strongly acidic milieu (pH is ~1.5–2.0), thereby generating NO, nitrous acid and RNS, which promote RSNO formation [31–36]. Gastric and plasma [RSNO] are increased after orally administered sodium NO2⁻ and NO3⁻ in hypertensive rats [35], plasma [RSNO] is increased after treatment with sodium nitrate (NaNO3) in mice with chronic ischemia [37], and gastric [RSNO] is increased after ingestion of inorganic NO3⁻ in humans [36,38].
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Feelish, M.Stamler, J.
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