MinireviewSequence and Functional Analysis of GLUT10: A Glucose Transporter in the Type 2 Diabetes-Linked Region of Chromosome 20q12–13.1☆
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Revisiting the roles of glucose transporters in skeletal muscle physiology: is GLUT10 a novel player?
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2023, Comparative Biochemistry and Physiology -Part A : Molecular and Integrative PhysiologyHexose Transporters in Cancer: From Multifunctionality to Diagnosis and Therapy
2021, Trends in Endocrinology and MetabolismExpression of glucose transporters in human neurodegenerative diseases
2021, Biochemical and Biophysical Research CommunicationsCitation Excerpt :It is rather localized intracellularly than at the plasma membrane [75]. It is a high affinity transporter for both deoxy-d-glucose and d-galactose, but not have an affinity for fructose [76]. GLUT12 (formerly designated GLUT8) is expressed in the human frontal cortex [77] and the mouse choroid plexus [78].
Expression of placental glucose transporter proteins in pregnancies complicated by fetal growth disorders
2021, Advances in Protein Chemistry and Structural BiologyCitation Excerpt :Therefore, isoforms that are essential for maternal-fetal glucose exchange in the early pregnancy period (e.g. GLUT-3) play only a minor role in the perinatal period, and vice versa (Brown, Heller, Zamudio, & Illsley, 2011). Over 30 years of studies on glucose transport has confirmed the presence of proteins GLUT-1, GLUT-3, GLUT-4, GLUT-8, GLUT-9 and GLUT-12, as well as mRNA of GLUT-10 and GLUT-11 in the placenta (Table 1) (Bibee, Illsley, & Moley, 2011; Dawson et al., 2001; Gude et al., 2003; Hauguel-De Mouzon et al., 1997; Limesand, Regnault, & Hay, 2004; Scheepers et al., 2005; Takata, Kasahara, Kasahara, Ezaki, & Hirano, 1992; Xing et al., 1998). Such a variety of isoforms implicates that maternal-fetal transport of glucose is a complex and highly regulated process.
Human placental glucose transport in fetoplacental growth and metabolism
2020, Biochimica et Biophysica Acta - Molecular Basis of DiseaseCitation Excerpt :There are few reports regarding the Class III isoform, GLUT10, in the human placenta. Its presence was determined in the early tissue surveys [45,46], and more recently it has been shown to demonstrate a significant degree of promoter methylation, increasing over gestation [47]. Placental localization and function are unknown, however studies in other species/tissues have suggested that GLUT10 has an intracellular localization, possibly to the endoplasmic reticulum [48], or the mitochondrion [49].
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The sequence reported in this paper has been deposited in GenBank Database (Accession Nos. AF248053 and AY029579) and given the HGMW approved symbol SLC2A10.
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To whom correspondence should be addressed at Department of Biochemistry, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157. Fax: (336) 716-7200. E-mail: [email protected].