Regular ArticleDexamethasone Suppresses Vascular Smooth Muscle Cell Proliferation☆
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Evaluation of drug-eluting nanoparticle coating on magnesium alloy for development of next generation bioabsorbable cardiovascular stents
2022, Medical Engineering and PhysicsCitation Excerpt :In addition, we demonstrated that increased Mg ion concentration is the main reason of decreased cell viability [68]. Although the effect of dexamethasone on SMCs has been shown by some studies [69,70], constant cell viability of Dexa group after 72 h has been observed in our study. It might indicate that Dexa in solution form had no effect on SMCs or this concentration was less to be effective.
Biodegradable nanoparticles for drug and gene delivery to cells and tissue
2012, Advanced Drug Delivery ReviewsCitation Excerpt :As shown above for cultured cells, nanoparticles may enter into the intracellular space by endocytosis, thus providing localized drug effects at a cellular level. This is important for certain drugs like dexamethasone because the receptors for this drug are intracellular [135]. Intracellular delivery is also important for gene therapy approaches to achieve greater level of gene expression.
The inhibitory effect of dexamethasone on platelet-derived growth factor-induced vascular smooth muscle cell migration through up-regulating PGC-1α expression
2011, Experimental Cell ResearchCitation Excerpt :Vascular smooth muscle cell (VSMC) migration is the critical event in the progression of neointimal thicking and restenosis [4]. Dexamethasone has been shown to suppress VSMC migration and proliferation [5,6]. Several animal studies demonstrated that dexamethasone exhibited beneficial effects on cholesterol-induced atherosclerosis and neointimal formation in arterial injury [7–10].
Design Principles in Biomaterials and Scaffolds
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Presented at the Annual Meeting of the Association for Academic Surgery, Seattle, Washington, November 18–22, 1998.
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To whom correspondence and reprint requests should be addressed at UCLA Center for Health Sciences, Department of Surgery, 10833 LeConte Ave., Los Angeles, CA 90095.