EditorialHas Angiogenesis Been Invited to the PPARty?
References (38)
- et al.
15-Deoxy-Δ12,14-prostaglandin J2 is a ligand for the adipocyte determination factor PPARγ
Cell
(1995) - et al.
A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation
Cell
(1995) - et al.
Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
Cell
(1998) - et al.
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
J Biol Chem
(1995) - et al.
PPAR signaling in the control of cardiac energy metabolism
Trends Cardiovasc Med
(2000) - et al.
Altered constitutive expression of fatty acid-metabolizing enzymes in mice lacking the peroxisome proliferator-activated receptor α (PPARα)
J Biol Chem
(1998) - et al.
The role of the peroxisome proliferator-activated receptor alpha (PPAR alpha) in the control of cardiac lipid metabolism
Prostaglandins Leukot Essent Fatty Acids
(1999) - et al.
Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor alpha associated with age-dependent cardiac toxicity
J Biol Chem
(2000) - et al.
A role for peroxisome proliferator-activated receptor alpha (PPARα) in the control of cardiac malonyl-CoA levels: reduced fatty acid oxidation rates and increased glucose oxidation rates in the hearts of mice lacking PPARalpha are associated with higher concentrations of malonyl-CoA and reduced expression of malonyl-CoA decarboxylase
J Biol Chem
(2002) - et al.
Hypoxia inhibits the peroxisome proliferator-activated receptor alpha/retinoid X receptor gene regulatory pathway in cardiac myocytes: a mechanism for O2-dependent modulation of mitochondrial fatty acid oxidation
J Biol Chem
(2001)
Hypoxia in vivo decreases peroxisome proliferator-activated receptor alpha-regulated geneexpression in rat heart
Biochem Biophys Res Commun
(2001)
Hypoxia regulates expression of the endothelin-1 gene through a proximal hypoxia-inducible factor-1 binding site on the antisense strand
Biochem Biophys Res Commun
(1998)
Altered gene expression during hypoxia and reoxygenation of the heart
Pharmacol Ther
(1999)
Prostaglandins up-regulate vascular endothelial growth factor production through distinct pathways in differentiated U937 cells
Biochem Biophys Res Commun
(2000)
Peroxisome proliferator-activated receptor-γ agonists increase vascular endothelial growth factor expression in human vascular smooth muscle cells
Biochem Biophys Res Commun
(2000)
Peroxisome proliferator-activated receptor γ ligands are potent inhibitors of angiogenesis in vitro andin vivo
J Biol Chem
(1999)
Isoform-specific regulation of vascular endothelial growth factor (VEGF) family mRNA expression in cultured mouse brown adipocytes
Mol Cell Endo
(2001)
Peroxisome proliferator-activated receptors: nuclear control of metabolism
Endocr Rev
(1999)
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome-proliferator-activted receptors α and δ
Proc Natl Acad Sci USA
(1997)
Cited by (6)
Structural basis for iloprost as a dual peroxisome proliferator-activated receptor α/δ agonist
2011, Journal of Biological ChemistryCitation Excerpt :The pharmacologic actions of PPARs are mediated first through their LBDs, which bind ligands, then recruit nuclear receptor coactivators (or corepressors) to regulate expression of the downstream target genes. Interestingly, PPARs have been revealed as important regulators in angiogenesis (12, 13). Indeed, some effects of iloprost in vivo, like angiogenesis and up-regulation of vascular endothelial growth factor, function through PPARα-dependent mechanisms (14, 15).
PPAR gamma: A novel pharmacological target against retinal and choroidal neovascularization
2005, Journal Francais d'OphtalmologieComparative analysis of the in vivo angiogenic properties of stable prostacyclin analogs: A possible role for peroxisome proliferator-activated receptors
2004, Journal of Molecular and Cellular CardiologyProstacyclins
2013, Handbook of Experimental PharmacologyEndothelial progenitor cells and angiogenesis join the PPARty
2008, Circulation ResearchProstacyclin therapies for the treatment of pulmonary arterial hypertension
2008, European Respiratory Journal
- f1
Please address all correspondence to: Philip M. Barger, MD, Winters Center for Heart Failure Research, Baylor College of Medicine, MS 524, 6565 Fannin St, Houston, Texas 77030, USA. Tel: (713)441-0421; Fax: (713)441-1252; E-mail:[email protected]
Copyright © 2002 Elsevier Science Ltd. All rights reserved.