Biochemical and Biophysical Research Communications
Regular ArticleA Novel Gene, CRR9, Which Was Up-Regulated in CDDP-Resistant Ovarian Tumor Cell Line, Was Associated with Apoptosis☆
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2021, The Lancet OncologyCo-exposure to multiple metals, TERT-CLPTM1L variants, and their joint influence on leukocyte telomere length
2020, Environment InternationalCitation Excerpt :As a telomerase regulatory gene, TERT encodes the catalytic subunit of telomerase and plays vital roles in maintaining telomerase expression and facilitating telomeric repeats elongation (Robles-Espinoza et al., 2015). CLPTM1L encodes the cleft lip and palate-associated transmembrane 1 like protein, which is associated with cisplatin-induced apoptosis (Yamamoto et al., 2001). Given the above findings that multiple metals exposure and genetic variations in the TERT-CLPTM1L cluster were both important determinants on telomere length, a critical question of interest is to integrate genome and exposome information in order to understand their combined effects.
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Abbreviations used: ABC, ATP binding cassette; CDDP, cisplatin; GFP, green fluorescent protein; HSP, heat shock protein; MDR, multi drug resistance; MLH, mutL homolog; MSH, mutS homolog; MRP, multi drug resistant protein; RACE, rapid amplification of cDNA ends.