Biomarker | Patients n | ROC analysis | |
AUC (95% CI) | p-value | ||
30-day mortality | 224 | ||
CRP*,#,¶ | 0.593 (0.525–0.658) | 0.294 | |
WBC*,#,¶ | 0.509 (0.442–0.577) | 0.927 | |
PCT*,#,¶ | 0.627 (0.560–0.691) | 0.089 | |
MR-proADM | 0.859 (0.807–0.902) | <0.0001 | |
PSI | 0.858 (0.805–0.901) | <0.0001 | |
PSI + MR-proADM# | 0.914 (0.869–0.948) | <0.0001 | |
CURB-65 | 0.851 (0.798–0.895) | <0.0001 | |
CURB-65 + MR-proADM | 0.900 (0.853–0.936) | <0.0001 | |
90-day mortality | 220 | ||
CRP*,#,¶ | 0.542 (0.474–0.609) | 0.561 | |
WBC*,#,¶ | 0.507 (0.439–0.576) | 0.926 | |
PCT*,#,¶ | 0.597 (0.529–0.663) | 0.108 | |
MR-proADM | 0.825 (0.768–0.873) | <0.0001 | |
PSI | 0.811 (0.753–0.860) | <0.0001 | |
PSI + MR-proADM# | 0.862 (0.809–0.905) | <0.0001 | |
CURB-65 | 0.832 (0.776–0.879) | <0.0001 | |
CURB-65 + MR-proADM¶ | 0.879 (0.828–0.919) | <0.0001 | |
180-day mortality | 218 | ||
CRP*,#,¶ | 0.552 (0.483–0.619) | 0.412 | |
WBC*,#,¶ | 0.540 (0.471–0.607) | 0.567 | |
PCT*,#,¶ | 0.585 (0.517–0.652) | 0.114 | |
MR-proADM | 0.792 (0.732–0.844) | <0.0001 | |
PSI | 0.781 (0.720–0.834) | <0.0001 | |
PSI + MR-proADM# | 0.822 (0.765–0.871) | <0.0001 | |
CURB-65 | 0.802 (0.743–0.853) | <0.0001 | |
CURB-65 + MR-proADM¶ | 0.845 (0.790–0.891) | <0.0001 | |
1-yr mortality | 150 | ||
CRP¶ | 0.658 (0.576–0.734) | 0.030 | |
WBC*,#,¶ | 0.636 (0.553–0.713) | 0.086 | |
PCT*,#,¶ | 0.641 (0.558–0.718) | 0.054 | |
MR-proADM | 0.803 (0.731–0.864) | <0.0001 | |
PSI | 0.793 (0.719–0.855) | <0.0001 | |
PSI + MR-proADM# | 0.828 (0.758–0.885) | <0.0001 | |
CURB-65 | 0.829 (0.759–0.886) | <0.0001 | |
CURB-65 + MR-proADM | 0.870 (0.806–0.920) | <0.0001 |
AUC: area under the curve; CRP: C-reactive protein; WBC: white blood cells; PCT, procalcitonin; MR: midregional; proADM: proadrenomedullin; PSI: Pneumonia Severity Index; CURB-65: confusion (abbreviated mental test score of ≤8), urea ≥7 mol·L−1, respiratory rate ≥30 breaths·min−1, blood pressure <90 mmHg systolic or <60 mmHg diastolic, and age ≥65 yrs; PSI + MR-proADM: logistic regression model combining MR-proADM levels with PSI risk score; CURB-65 + MR-proADM: logistic regression model combining MR-proADM levels with CURB-65 risk score. Bonferroni correction was applied (p≤0.00156). Bold indicates statistically significant p-values. *: p<0.05 for comparison of AUCs with that of MR-proADM; #: p<0.05 for comparison of AUCs with that of PSI; ¶: p<0.05 for comparison of AUCs with that of CURB-65.