Table 2– Unadjusted and adjusted ratios of asthma score per 10-fold increase of endotoxin levels with 95% confidence intervals for the entire sample and stratified by CD14 genotype

	Participants			CD14/-260 genotype			p-value
	All	Full confounder information	Full confounders and genotype	CC	CT	TT	Heterogeneity of effect	Trend of interaction^#
Participants n	972	872	552	120	283	149
Asthma score
Continuous^¶
Unadjusted	1.16 (0.93–1.46)	1.14 (0.90–1.44)	1.15 (0.85–1.54)	0.55 (0.27–1.10)	1.82 (1.20–2.74)	1.02 (0.59–1.77)	0.011	0.291
Adjusted⁺		1.12 (0.88–1.43)	1.12 (0.82–1.52)	0.63 (0.31–1.27)	1.86 (1.19–2.91)	1.11 (0.61–2.01)	0.032	0.374
Binary^§
Unadjusted	1.18 (0.89–1.57)	1.14 (0.84–1.54)	1.11 (0.76–1.63)	0.44 (0.18–1.06)	2.01 (1.13–3.56)	1.00 (0.5–2.00)	0.015	0.201
Adjusted⁺		1.14 (0.83–1.57)	1.10 (0.73–1.65)	0.49 (0.18–1.31)	2.12 (1.15–3.91)	0.96 (0.43–2.13)	0.033	0.267

^#: assuming additive model; ^¶: continuous measure ranging from 0 to 5; ⁺: confounders were age, sex, smoking status in pack-yrs and household variables (keeping a cat or dog, age of mattress, presence of mould in bedroom, presence of damp in bedroom, household density, and age of home); ^§: binary measure comparing positive answers to any of the five questions with negative answers to all five.