Table 2– Exhaled nitric oxide fraction (FeNO) and lung function in healthy control subjects and wheezers, and multiple linear regression analyses showing the effect of wheeze on outcome measures
VariableHealthy controlsWheezersMultiple linear regression analyses
Adjusted coefficients# (95% CI)p-valuer2 for model
Subjects n7228
FeNO ppb4.8 (3.2–7.6)4.9 (3.7–11.4)1.1 (0.8–1.7)0.5420.036
LCI6.6 (6.2–6.9)6.8 (6.6–7.5)1.1 (1.0–1.2)0.0020.204
Scond0.016 (0.005–0.026)0.046 (0.016–0.065)3.0 (1.7–5.2)<0.00050.259
Sacin0.048 (0.029–0.067)0.059 (0.033–0.089)1.3 (0.9–1.8)0.1860.040
sRaw kPa·s1.03 (0.91–1.19)1.18 (0.88–1.59)1.2 (1.1–1.3)0.0020.143
  • Data are presented as median (interquartile range), unless otherwise stated. Bold indicates statistical significance. LCI: lung clearance index; Scond: conducting zone contribution to ventilation inhomogeneity; Sacin: acinar zone contribution to ventilation inhomogeneity; sRaw: specific airway resisance. #: coefficients were exponentiated and represent the multiplicative effect of wheeze on FeNO and lung function outcome.