Table 3– Results of univariate and multivariate proportional hazards modelling of changes in variables between baseline and follow-up
VariablesUnivariate modelMultivariate model
HR (95% CI)p-valueHR (95% CI)p-value
Functional capacity
 ΔWHO functional class2.0 (1.1–3.6)0.021.4 (1.2–2.4)0.04
 Δ6-MWD0.91 (0.94–1.1)0.08
Haemodynamic variables
 ΔRA pressure mmHg0.98 (0.94–1.0)0.37
 Δpa mmHg0.81 (0.69–1.1)0.29
 ΔCardiac index L·min−1·m−22.1 (1.2–3.9)0.011.8 (1.1–2.9)0.02
 ΔPVR dyn·sec·cm−50.94 (0.8–1.2)0.28
 ΔSv,O2 %2.1 (1.2–3.6)0.0082.2 (1.2–4.2)0.01
 ΔSVI mL·m−2·beat−11.3 (0.6–2.8)0.49
 ΔCapacitance mL·mmHg−11.2 (0.8–1.7)0.5
Biochemical variables
 ΔNT-proBNP ng·L−12.4 (1.3–4.5)0.0031.3 (1.2–1.8)0.007
 ΔBilirubin μmol·L−11.2 (0.9–1.3)0.08
 ΔγGT U·L−11.4 (0.8–2.5)0.32
 ΔCreatinine μmol·L−11.2 (0.6–2.0)0.55
 ΔBUN mmol·L−11.2 (1.1–1.3)0.03
 ΔUric acid μmol·L−11.3 (0.8–2.3)0.25
 ΔCRP mg·L−11.4 (0.7–2.7)0.24
 ΔRDW %0.9 (0.4–1.8)0.79
 ΔS-Na+ mmol·L−11.1 (1.0–1.3)0.03
  • HR: hazard ratio; CI: confidence interval; WHO: World Health Orrganization; 6-MWD: 6-min walk distance; RA: right atrial; pa: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; Sv,O2: mixed-venous oxygen saturation; SVI: stroke volume index; NT-proBNP: N-terminal pro-brain natriuretic peptide; γGT,: gamma-glutamyltransferase; BUN: blood urea nitrogen; CRP: C-reactive protein; RDW: red cell distribution width; S-Na+: serum sodium level.