Table 3– Results of univariate and multivariate proportional hazards modelling of changes in variables between baseline and follow-up

Variables	Univariate model		Multivariate model
	HR (95% CI)	p-value	HR (95% CI)	p-value
Functional capacity
ΔWHO functional class	2.0 (1.1–3.6)	0.02	1.4 (1.2–2.4)	0.04
Δ6-MWD	0.91 (0.94–1.1)	0.08
Haemodynamic variables
ΔRA pressure mmHg	0.98 (0.94–1.0)	0.37
ΔP̄_pa mmHg	0.81 (0.69–1.1)	0.29
ΔCardiac index L·min⁻¹·m⁻²	2.1 (1.2–3.9)	0.01	1.8 (1.1–2.9)	0.02
ΔPVR dyn·sec·cm⁻⁵	0.94 (0.8–1.2)	0.28
ΔS_v,O₂ %	2.1 (1.2–3.6)	0.008	2.2 (1.2–4.2)	0.01
ΔSVI mL·m⁻²·beat⁻¹	1.3 (0.6–2.8)	0.49
ΔCapacitance mL·mmHg⁻¹	1.2 (0.8–1.7)	0.5
Biochemical variables
ΔNT-proBNP ng·L⁻¹	2.4 (1.3–4.5)	0.003	1.3 (1.2–1.8)	0.007
ΔBilirubin μmol·L⁻¹	1.2 (0.9–1.3)	0.08
ΔγGT U·L⁻¹	1.4 (0.8–2.5)	0.32
ΔCreatinine μmol·L⁻¹	1.2 (0.6–2.0)	0.55
ΔBUN mmol·L⁻¹	1.2 (1.1–1.3)	0.03
ΔUric acid μmol·L⁻¹	1.3 (0.8–2.3)	0.25
ΔCRP mg·L⁻¹	1.4 (0.7–2.7)	0.24
ΔRDW %	0.9 (0.4–1.8)	0.79
ΔS-Na⁺ mmol·L⁻¹	1.1 (1.0–1.3)	0.03

HR: hazard ratio; CI: confidence interval; WHO: World Health Orrganization; 6-MWD: 6-min walk distance; RA: right atrial; P̄_pa: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; S_v,O₂: mixed-venous oxygen saturation; SVI: stroke volume index; NT-proBNP: N-terminal pro-brain natriuretic peptide; γGT,: gamma-glutamyltransferase; BUN: blood urea nitrogen; CRP: C-reactive protein; RDW: red cell distribution width; S-Na⁺: serum sodium level.