Table 2– Results of univariate and multivariate proportional hazards modelling of baseline variables
VariablesUnivariate modelMultivariate model
HR (95% CI)p-valueHR (95% CI)p-value
Functional capacity
 WHO functional class2.3 (1.0–5.1)0.04
 6-MWD1.2 (1.0–1.3)0.0021.5 (1.0–1.8)0.04
Haemodynamic variables
 RA pressure mmHg1.2 (1.0–1.3)0.0011.1 (1.0–1.3)0.001
pa mmHg1.0 (0.9–1.1)0.18
 Cardiac index L·min−1·m−21.7 (1.4–2.6)0.011.8 (1.4–2.3)<0.001
 PVR dyn·sec·cm−51.0 (0.8–1.1)0.42
Sv,O2 %1.2 (1.1–1.4)0.021.6 (1.2–2.2)<0.001
 SVI mL·m−2·beat−10.96 (0.9–1.1)0.11
 Capacitance mL·mmHg−10.95 (0.6–1.4)0.76
Biochemical variables
 NT-proBNP ng·L−11.3 (1.1–1.6)0.041.2 (1.1–1.4)0.04
 Bilirubin μmol·L−11.1 (1.0–1.3)0.023
 γGT U·L−11.0 (0.9–1.2)0.07
 Creatinine μmol·L−11.4 (1.2–1.9)0.04
 BUN mmol·L−11.1 (0.9–1.2)0.06
 Uric acid μmol·L−11.1 (1.0–1.6)0.01
 CRP mg·L−11.3 (1.1–1.6)0.04
 RDW %1.1 (0.6–1.2)0.16
 S-Na+ mmol·L−11.07 (0.9–1.2)0.19
  • HR: hazard ratio; CI: confidence interval; WHO: World Health Organization; 6-MWD: 6-min walk distance; RA: right atrial; pa: mean pulmonary arterial pressure; PVR: pulmonary vascular resistance; Sv,O2: mixed-venous oxygen saturation; SVI: stroke volume index; NT-proBNP: N-terminal pro-brain natriuretic peptide; γGT: gamma-glutamyltransferase; BUN: blood urea nitrogen; CRP: C-reactive protein; RDW: red cell distribution width; S-Na+: serum sodium level.