Table 1– Clinical characteristics of patients with radiographic stage IV disease
Subjects n142
Demography#
 Males/females74 (52.1)/68 (47.9)
 Age yrs48.1±12 (15.4–73.7)
 Caucasian/black/others92 (64.8)/45 (31.7)/5 (3.5)
 Non-smokers/ex- or current smokers87 (61.3)/55 (38.8)
 Smoking exposure pack-yrs16.1±14.5 (1–60)
Clinical symptoms#
 NYHA functional class I/II/III/IV19 (13.4)/69.7 (99)/13.4 (19)/3.5 (5)
 Cough73 (51.4)
 Sputum26 (18.3)
 Haemoptysis4 (2.8)
 Crackles40 (28.2)
 Wheezing8 (5.6)
 Digital clubbing9 (6.3)
Duration of sarcoidosis yrs5.8±6.2 (0–27)+
Extrarespiratory involvement of sarcoidosis
 Presence of any type of involvement106 (74.6)
 Median number of involved organs (range)2 (0–6)
 Presence of severe manifestations44 (31)§
  • Data are presented as n (%) or mean±sd (range), unless otherwise stated. NYHA: New York Heart Association. #: at first evaluation with radiographic stage IV;: at some point of sarcoidosis course; +: 39 (27.5%) patients were diagnosed simultaneously with sarcoidosis and radiographic stage IV disease; §: severe extrarespiratory manifestations included ophthalmic localisation unresponsive to local therapy in 24 patients, heart involvement in 23, central nervous system involvement in seven and hypercalcaemia in one.