CD14/-260 genotype | p-value | |||||

CC | CT | TT | Heterogeneity of effect | Trend of interaction^{¶} | Test of difference in effect of CD14 on lung function response to endotoxin^{+} | |

FEV_{1}, adjusted^{§} | ||||||

Nonatopics | 0.46 (-0.03–0.96) (n=84) | 0.08 (-0.21–0.38) (n=191) | -0.39 (-0.78– -0.01) (n=104) | 0.028 | 0.004 | 0.091 |

Atopics | 1.11 (0.67–1.55) (n=26) | -0.13 (-0.71–0.43) (n=79) | 0.16 (-0.67–1.00) (n=41) | 0.001 | 0.273 | |

FVC, adjusted^{§} | ||||||

Nonatopics | 0.57 (0.01–1.13) (n=84) | 0.004 (-0.31–0.32) (n=190) | -0.45 (-0.82– -0.08) (n=104) | 0.008 | 0.009 | 0.260 |

Atopics | 0.42 (-0.35–1.20) (n=26) | -0.02 (-0.59–0.55) (n=80) | -0.04 (-0.82–0.73) (n=41) | 0.615 | 0.900 | |

FEV_{1}/FVC, adjusted^{§} | ||||||

Nonatopics | -0.12 (-0.58–0.33) (n=84) | 0.06 (-0.20–0.33) (n=190) | 0.28 (-0.07–0.65) (n=104) | 0.362 | 0.194 | 0.107 |

Atopics | 1.44 (0.60–2.27) (n=26) | 0.02 (-0.50–0.55) (n=80) | 0.31(-0.25–0.88) (n=41) | 0.018 | 0.221 |

Data are presented with 95% confidence intervals.

^{#}: a male of age 50 yrs and height 180 cm is predicted to have a FEV_{1}of 3.8 L using the equation of Quanjer*et al.*[17]. If his observed FEV_{1}is 4 L, then the difference between observed and predicted FEV_{1}is 0.2 L. Following standardisation (again using the standard deviation provided by Quanjer*et al.*[17]), his standardised residual is 0.38. This means the difference between his measured and predicted FEV_{1}is 0.38 standard deviations greater than the mean of all of these values.^{ ¶}: additive model.^{ +}: comparing atopics and nonatopics, p-value of hypothesis that a linear effect of a three-way interaction term (endotoxin×*CD14*/-260C to T×atopy) is equal to 0.^{ §}: confounders were age, sex, smoking status in pack-yrs and household variables (keeping a cat or dog, age of the mattress, presence of mould in bedroom, presence of damp in bedroom, household density and age of home).