Subjects | OR | Sensitivity | Specificity | PPV | NPV | |
Wheezing within the first 6 months | 276 | 4.3 (2.2–8.5) | 43.5 (29.2–58.8) | 84.8 (79.3–89) | 36.4 (24.1–50.5) | 88.2 (83.1–92) |
Maternal atopy/atopic disease | 392 | 1.2 (0.67–1.9) | 37.3 (26–50.1) | 65.8 (60.4–70.9) | 18.4 (12.5–26.1) | 83.6 (78.4–87.8) |
Eczema within the first 6 months | 276 | 0.92 (0.36–2.4) | 13.0 (5.4–27) | 86.0 (80.7–90.1) | 15.8 (6.6–31.9) | 83.1 (77.6–87.5) |
High FeNO (>17.5 ppb) | 392 | 1.3 (0.72–2.34) | 28.4 (18.3–40.9) | 76.6 (71.6–81) | 20.0 (12.8–29.7) | 83.8 (79–87.7) |
Clinical index# | 276 | 5.3 (2.3–11.9) | 28.2 (16.5–43.7) | 93.0 (88.7–95.8) | 44.8 (26.9–64) | 86.6 (81.6–90.5) |
Composite index¶ | 276 | 4.6 (2.2–9.8) | 32.6 (19.9–48.1) | 90.4 (85.7–93.8) | 40.5 (25.2–57.8) | 87.0 (81.9–90.9) |
Data are presented as n or value (95% CI). PPV: positive predictive value; NPV: negative predictive value; FeNO: exhaled nitric oxide fraction. #: wheezing within the first 6 months plus eczema or maternal atopy/atopic disease; ¶: wheezing within the first 6 months plus eczema or maternal atopy/atopic disease plus FeNO > 7.5 ppb.