Table 2– Pharmacological inhibitors used to screen for mechanisms of CXC chemokine ligand 8 regulation
InhibitorConcentration μMTarget
SB2021905p38
PD9805910MEK1/2 (ERK1/2)
SP60012510JNK
PP25Src-family kinases
AG14785EGFR
Gö69763PKCα/β1
Rottlerin3PKCδ/θ
GF109203X3PKC (general)
H-850PKA
Wortmannin0.1PI3K
AG49010JAK2/3
Verapamil100Ca2+ channels
BAPTA-AM20Ca2+ chelator
W-725Calmodulin (Ca2+)
Curcumin10Multiple targets including NF-κB and AP-1
  • PP: protein phosphatase; BAPTA-AM: 1,2-bis(2-aminophenoxy)ethane-N,N,NN′-tetraacetic acid tetrakis (acetoxymethyl ester); ERK: extracellular signal regulated-kinase; JNK: c-Jun N-terminal kinase; EGFR: epidermal growth factor receptor; PK: protein kinase; PI3K: phosphoinositide 3-kinase; JAK: Janus kinase; NF: nuclear factor; AP: activator protein.