Table 3– Correlations between measured parameters and time post haematopoietic stem cell transplantation
ParametersUnivariate correlationsIndependent predictors#
rp-valuePartial r2p-value
Pulmonary function % pred
FEV1-0.58<0.0010.240.02
FVC-0.440.01
 FEV1/FVCrs = -0.300.10
 FEF25–75%-0.410.02
 TLC0.200.25
 Log RV/TLC0.410.02
DL,CO0.070.69
MBNW
Log LCI0.62<0.001
Scond0.450.01+
Log Sacin0.62<0.001§0.180.04ƒ
FOT % pred
Rrsrs = -0.010.97
Log Xrsr=0.510.002+
eNO (log)r=0.050.77
  • FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; FEF25–75%: forced expiratory volume at 25–75% of FVC; TLC: total lung capacity; RV: residual volume; DL,CO: diffusing capacity of the lung for carbon monoxide; MBNW: multiple breath nitrogen washout; LCI: lung clearance index; Scond: index of conductive airways heterogeneity; Sacin: index of diffusive airways heterogeneity; FOT: forced oscillation technique; Rrs: respiratory system resistance; Xrs: respiratory system reactance; eNO: exhaled nitric oxide. #: independent predictors of time post transplant in multiple regression model including significant parameters (in italics) from univariate analyses; : insignificant after removing the two patients with longest time post-transplant; +: insignificant after removing the two patients with highest measured values; §: after correction for age and smoking history (confounding factors), the correlation was still highly significant (r=0.55, p=0.001); ƒ: Sacin corrected for confounding factors was used in the multiple regression model. Italics indicates significant univariate correlations after correction for multiple comparisons.