6MWT at baseline | 6MWT on oxygen# | p-value | |
In all ILD patients¶ | |||
Distance m | 255.1±16.8 | 286.0±14.9 | <0.00001 |
Sa,O2 end test % | 76.3±1.1 | 84.7±1.1 | <0.00001 |
Borg scale end test+ | 4.75 (4–5) | 3.75 (3–4.3) | <0.00001 |
Heart rate end test | 120.4±2.0 | 115.9±2.3 | 0.03 |
Heart rate recovery time s | 218.5±19.9 | 145.5±10.4 | <0.00001 |
Borg score recovery time s | 185.3±21.2 | 133.7±12.8 | 0.0002 |
Sa,O2 recovery time s | 183.6±20.2 | 102.7±8.5 | <0.00001 |
In patients who completed both 6MWTs without stops§ | |||
Distance m | 318.9±15.4 | 332.3±15.1 | 0.002 |
Sa,O2 end test % | 78.2±1.2 | 86.7±1.1 | <0.00001 |
Borg scale end test+ | 4.0 (3–5) | 3.5 (2.5–4) | <0.00001 |
Heart rate end test | 118.6±2.6 | 112.5±3.1 | 0.04 |
Heart rate recovery time s | 210.4±27.6 | 132.3±11.9 | 0.001 |
Borg score recovery time s | 175.1±29.6 | 116.0±16.1 | 0.001 |
Sa,O2 recovery time s | 162.2±24.2 | 83.8±8.3 | 0.0005 |
In patients who stopped at least once during the baseline 6MWTƒ | |||
Distance m | 144.2±19.2 | 205.6±21.2 | 0.0001 |
Sa,O2 end test % | 73±2.0 | 81.3±2.0 | <0.00001 |
Borg scale end test+ | 5 (4–6.7) | 5 (3.3–6.0) | 0.02 |
Heart rate end test | 123.5±3.1 | 121.9±3.2 | ns |
Heart rate recovery time s | 231.9±27.2 | 167.8±18.5 | 0.0007 |
Borg score recovery time s | 203.2±27.4 | 164.5±19.6 | 0.07 |
Sa,O2 recovery time s | 220.6±35.3 | 135.7±15.8 | 0.004 |
In fibrotic IIP patients## | |||
Distance m | 272.3±19.8 | 304.7±17.8 | 0.0001 |
Sa,O2 end test % | 75.6±1.1 | 83.4±1.3 | <0.00001 |
Borg scale end test+ | 4.25 (3–5) | 3.25±(2.5–4) | <0.00001 |
Heart rate end test | 119.6±2.5 | 116.6±3.0 | ns |
Heart rate recovery time s | 214.3±25.9 | 138.1±12.4 | 0.0003 |
Borg score recovery time s | 167.1±28.2 | 120.7±15.5 | 0.008 |
Sa,O2 recovery time s | 177.4±24.2 | 104.0±10.5 | 0.0007 |
All values are expressed as mean±se unless stated otherwise. ILD: interstitial lung disease; Sa,O2: arterial oxygen saturation; IIP: idiopathic fibrotic interstitial pneumonia. #: additional or increased; ¶: n=52; +: median (95% CI); §: n=33; ƒ: n=19; ##: n=34.