| TRV <2.5 m·s−1 plus TRV ≥2.5 m·s−1 and P̄pa <25 mmHg | P̄pa ≥25 mmHg | p-value | |
| Subjects n | 66 | 8 | |
| Age yrs | 31.3±11.6 | 45.6±11 | 0.04 |
| Females % | 64.6 | 37.5 | 0.3 |
| BMI kg·m−2 | 20.8±2.65 | 20.1±2.8 | 0.5 |
| Left ventricle ejection fraction % | 64.2±7.1 | 62.5±6 | 0.53 |
| 6MWT m | 53±71 | 460±152 | 0.02 |
| O2 saturation % | 92.1±6.12 | 87.5±7.41 | 0.77 |
| Clinical history | |||
| Hydroxyurea use | 15.4 | 12.5 | 0.4 |
| Priapism | 62.5 | 80 | 0.47 |
| Hepatitis C | 24.6 | 25 | 0.33 |
| Leg ulcer | 23.1 | 37.5 | 0.41 |
| Proteinuria | 30.7 | 87.5 | 0.02 |
| DVT | 7.7 | 37.5 | 0.04 |
| Ischaemic stroke | 15.4 | 0 | 0.22 |
| ACS | 16.6 | 12.5 | 0.62 |
| Haematological findings | |||
| Hb g·L−1 | 84.4±12 | 73±10.2 | 0,01 |
| Leukocytes ×109 cells·L−1 | 11±3.4 | 12.1±4.27 | 0.58 |
| Reticulocytes % | 11±5.3 | 13.5±6.5 | 0.23 |
| Platelets ×109 cells·L−1 | 420±122 | 308±137 | 0.02 |
| Fetal Hb % | 7.8±5.7 | 6.21±3.44 | 0.9 |
| LDH U·L−1 | 1041±535 | 1596±424 | 0.006 |
| Uric acid mmol·L−1 | 282.5±109 | 516±81.5 | <0.001 |
| AST U·L−1 | 46.3±18.8 | 61.2±25.5 | 0.04 |
| GGT U·L−1 | 82.2±61.7 | 135±64.3 | 0.34 |
| Unconjugated bilirubin μmol·L−1 | 55.7±28 | 72.84±65 | 0.22 |
| C-reactive protein ng·mL−1 | 5.28±5.5 | 6.36±4 | 0.61 |
| BUN mmol·L−1 | 7.74±3.57 | 18.6±11.5 | <0.001 |
| Creatinine μmol·L−1 | 56.6±21.1 | 99±45.9 | <0.001 |
Data are presented as mean±sd, unless otherwise stated. TRV: tricuspid regurgitant jet velocity; P̄pa: mean pulmonary artery pressure; BMI: body mass index; 6MWT: 6-min walk test; DVT: deep venous thrombosis; ACS: acute chest syndrome; Hb: haemoglobin; LDH: lactate dehydrogenase; AST: aspartate transaminase; GGT: γ-glutamyltransferase; BUN: blood urea nitrogen.