Table 2– Bronchoalveolar lavage fluid cytokine levels
CytokineGPAIPFNormal
ActiveRemission
CXCL8 pg·mL−1422.8 (314.0)*2725.0 (13527.9)*329.0 (868.3)*30.5 (58.0)
IL-1β pg·mL−14.0 (41.5)74.9 (306.3)18.6 (41.1)3.8 (1.6)
ENA-78 pg·mL−1259.3 (761.3)*153.4 (263.5)*325.7 (475.4)*7.3 (41.4)
G-CSF pg·mL−156.4 (132.3)74.3 (143.4)68.6 (78.2)26.1 (15.7)
GM-CSF pg·mL−15.9 (6.3)4.0 (2.8)8.4 (4.9)1.0 (6.4)
  • Data are presented as median (interquartile range). There were no significant differences between disease cohorts. All cytokine concentrations were measured by ELISA (R&D Systems, Abingdon, UK). GPA: granulomatosis with polyangiitis (Wegener’s); IPF: idiopathic pulmonary fibrosis; CXCL: CXC chemokine ligand; IL: interleukin; ENA: epithelial neutrophil-activating protein; G-CSF: granulocyte colony-stimulating factor; GM-CSF: granulocyte-macrophage colony-stimulating factor. *: p<0.05 compared with normal controls when compared using Kruskal–Wallis and Dunn’s tests.