Phenotype | Gene | Polymorphism | β# | p-value |
Fibrosis | GSTT1 | Deletion | -0.09 | 0.003 |
GSTM1 | Deletion | -0.024 | 0.431 | |
GSTM3 | rs1799735 | -0.30 | 0.329 | |
rs1332018 | 0.005 | 0.180 | ||
GSTP1 | rs1695 | 0.002 | 0.937 | |
EPHX1 | rs1051740 | -0.025 | 0.410 | |
rs2234922 | -0.014 | 0.656 | ||
Putative phenotype | 0.017 | 0.571 | ||
NAT2 | rs1041983 | 0.001 | 0.962 | |
rs45532639 | -0.046 | 0.130 | ||
Acetylator status | 0.043 | 0.153 | ||
Pleural plaques | ||||
Greatest thickness | GSTT1 | Deletion | 0.016 | 0.604 |
GSTM1 | Deletion | -0.008 | 0.009 | |
GSTM3 | rs1799735 | 0.008 | 0.802 | |
rs1332018 | 0.004 | 0.890 | ||
GSTP1 | rs1695 | -0.003 | 0.912 | |
EPHX1 | rs1051740 | -0.013 | 0.676 | |
rs2234922 | -0.004 | 0.903 | ||
Putative phenotype | 0.010 | 0.750 | ||
NAT2 | rs1041983 | -0.22 | 0.454 | |
rs45532639 | -0.006 | 0.850 | ||
Acetylator status | 0.039 | 0.189 | ||
Extent | GSTT1 | Deletion | 0.017 | 0.588 |
GSTM1 | Deletion | -0.055 | 0.071 | |
GSTM3 | rs1799735 | 0.021 | 0.481 | |
rs1332018 | -0.001 | 0.962 | ||
GSTP1 | rs1695 | 0.020 | 0.519 | |
EPHX1 | rs1051740 | -0.018 | 0.547 | |
rs2234922 | -0.034 | 0.268 | ||
Putative phenotype | -0.004 | 0.900 | ||
NAT2 | rs1041983 | -0.43 | 0.157 | |
rs45532639 | 0.005 | 0.858 | ||
Acetylator status | 0.041 | 0.178 | ||
Calcification | GSTT1 | Deletion | 0.042 | 0.146 |
GSTM1 | Deletion | -0.016 | 0.573 | |
GSTM3 | rs1799735 | -0.029 | 0.316 | |
rs1332018 | 0.019 | 0.516 | ||
GSTP1 | rs1695 | 0.051 | 0.080 | |
EPHX1 | rs1051740 | -0.016 | 0.591 | |
rs2234922 | -0.002 | 0.943 | ||
Putative phenotype | 0.011 | 0.706 | ||
NAT2 | rs1041983 | -0.037 | 0.199 | |
rs45532639 | 0.043 | 0.136 | ||
Acetylator status | -0.009 | 0.769 |
Covariates used in the analysis: sex, age, smoking exposure in pack-years and asbestos exposure in years. #: standardised coefficient.