Table 2– Association between genetic polymorphisms and pleural plaques
PhenotypeGenePolymorphismβ#p-value
FibrosisGSTT1Deletion-0.090.003
GSTM1Deletion-0.0240.431
GSTM3rs1799735-0.300.329
rs13320180.0050.180
GSTP1rs16950.0020.937
EPHX1rs1051740-0.0250.410
rs2234922-0.0140.656
Putative phenotype0.0170.571
NAT2rs10419830.0010.962
rs45532639-0.0460.130
Acetylator status0.0430.153
Pleural plaques
 Greatest thicknessGSTT1Deletion0.0160.604
GSTM1Deletion-0.0080.009
GSTM3rs17997350.0080.802
rs13320180.0040.890
GSTP1rs1695-0.0030.912
EPHX1rs1051740-0.0130.676
rs2234922-0.0040.903
Putative phenotype0.0100.750
NAT2rs1041983-0.220.454
rs45532639-0.0060.850
Acetylator status0.0390.189
 ExtentGSTT1Deletion0.0170.588
GSTM1Deletion-0.0550.071
GSTM3rs17997350.0210.481
rs1332018-0.0010.962
GSTP1rs16950.0200.519
EPHX1rs1051740-0.0180.547
rs2234922-0.0340.268
Putative phenotype-0.0040.900
NAT2rs1041983-0.430.157
rs455326390.0050.858
Acetylator status0.0410.178
 CalcificationGSTT1Deletion0.0420.146
GSTM1Deletion-0.0160.573
GSTM3rs1799735-0.0290.316
rs13320180.0190.516
GSTP1rs16950.0510.080
EPHX1rs1051740-0.0160.591
rs2234922-0.0020.943
Putative phenotype0.0110.706
NAT2rs1041983-0.0370.199
rs455326390.0430.136
Acetylator status-0.0090.769
  • Covariates used in the analysis: sex, age, smoking exposure in pack-years and asbestos exposure in years. #: standardised coefficient.