| Characteristic | Trial | |||||
| ELCWP 1922 [9] | ELCWP 1923 [8] | ELCWP 1994 | All ELCWP trials | Paesmans et al. [4] | Sculier et al. [2] | |
| Subjects | 204 | 233 | 256 | 693 | 763 | 6609 |
| Sex | ||||||
| Male | 163 (80) | 196 (84) | 211 (82) | 570 (82) | 689 (90) | 4368 (66) |
| Female | 41 (20) | 37 (16) | 45 (18) | 123 (18) | 74 (10) | 2241 (34) |
| Age yrs | 59 (32–75) | 61 (34–74) | 61 (40–83) | 60 (32–84) | NR | NR |
| Karnofsky performance status | ||||||
| 60–70 | 14 (7) | 57 (24) | 64 (25) | 135 (19) | 250 (33) | 1409 (21) |
| 80–90 | 190 (93) | 176 (76) | 192 (75) | 558 (81) | 513 (67) | 5200 (79) |
| 100 | 88 (43) | 41 (18) | 31 (12) | 160 (23) | NR | 2039 (31) |
| Disease extent | ||||||
| Limited | 204 (100) | 18 (8) | 16 (6) | 238 (34) | 365 (48) | 2870 (43) |
| Very limited | 204 | 1 | 0 | 205 | NR | NR |
| Extensive | 215 (92) | 240 (94) | 455 (66) | 398 (52) | 3739 (57) | |
| >2 metastatic sites | 30 | 53 | 83 | NR | NR | |
| Pleural effusion | ||||||
| Not documented | 204 (100) | 200 (86) | 219 (86) | 623 (90) | NR | NR |
| Yes | 33 (14) | 37 (14) | 70 (10) | |||
| White blood cell count | ||||||
| <10 IU | 152 (75) | 155 (67) | 153 (60) | 460 (66) | 516 | NR |
| ≥10 IU | 52 (25) | 78 (33) | 100 (39) | 230 (33) | 241 | |
| Not reported | 3 (1) | 3 (<1) | 6 | |||
| Relative neutrophil count | ||||||
| ≤75% | 166 (81) | 154 (66) | 152 (59) | 472 (68) | 528 (69) | NR |
| >75% | 35 (17) | 74 (32) | 68 (27) | 177 (26) | 212 (28) | |
| NR | 3 (1) | 5 (2) | 36 (14) | 44 (6) | 23 (3) | |
| Alkaline phosphatases | ||||||
| Normal | 101 (50) | 69 (30) | 107 (42) | 277 (40) | 297 | NR |
| Abnormal | 77 (38) | 158 (68) | 144 (56) | 379 (55) | 431 | |
| NR | 26 (13) | 6 (3) | 5 (2) | 37 (5) | 35 | |
| Creatinine | ||||||
| Normal | 199 (98) | 225 (97) | 249 (97) | 673 (97) | NR | NR |
| Abnormal | 3 (1) | 6 (3) | 4 (2) | 13 (2) | ||
| NR | 2 (1) | 2 (1) | 3 (1) | 7 (1) | ||
| LDH | ||||||
| Normal | 144 (71) | 123 (53) | 127 (50) | 394 (57) | NR | NR |
| Abnormal | 30 (15) | 88 (38) | 98 (38) | 216 (31) | ||
| NR | 30 (15) | 22 (9) | 31 (12) | 83 (12) | ||
Data are presented as n, n (%) or median (range). ELCWP: European Lung Cancer Working Party; NR: not reported; LDH: lactate dehydrogenase.