Table 3– Multivariable Cox regression model#
ParameterHR (95% CI)p-valueRisk points
Males1.7 (1.2–2.5)0.0031
No chills11
Chills0.6 (0.4–1)0.0490
Initial temperature in quartiles
 <37.0°C11
 37.0–37.9°C0.8 (0.5–1.3)0.3911
 37.9–38.7°C0.9 (0.6–1.5)0.7491
 >38.7°C0.4 (0.2–0.6)<0.0010
Age in quartiles
 <59 yrs10
 59–73 yrs1.5 (0.7–3.1)0.2551
 73–82 yrs2 (1–4)0.0662
 >82 yrs3 (1.5–6.1)0.0023
Comorbidities
 Chronic heart failure0.8 (0.6–1.2)0.3690
 COPD1.5 (1.1–2.1)0.0201
 Neoplastic disease2.5 (1.7–3.7)<0.0012
 Chronic renal failure1 (0.7–1.5)0.9580
Initial blood markers
 ProADM
  <0.83 nmol·L−1¶,+10
  0.83–1.22 nmol·L−10.9 (0.5–1.7)0.8210
  1.22–1.97 nmol·L−11.9 (1.1–3.5)0.0322
  >1.97 nmol·L−13.3 (1.7–6.2)<0.0013
 CRP
  <105 mg·dL−1¶,+13
  105–181 mg·dL−10.8 (0.5–1.2)0.2882
  181–265 mg·dL−10.7 (0.5–1.2)0.1871
  >265 mg·dL−10.3 (0.2–0.5)<0.0010
  • COPD: chronic obstructive pulmonary disease; pro-ADM: pro-adrenomedullin; CRP: C-reactive protein. #: n = 877; : reference group; +: peak levels during hospitalisation were used.