Table 6– Performance of lung function parameters in differentiating subjects with chronic lung disease of infancy from controls
ParameterCriteriaSensitivity %Specificity %+LRAUC
Z-FVC≤ -2.03 (0.1–14)98 (92–99)1 (0.2–8)0.56 (0.47–0.65)
Z-FEV0.5≤ -2.03 (0.1–13)97 (92–99)1 (0.2–8)0.61 (0.52–0.70)
Z-FEF50%≤ -2.05 (3–25)96 (89–99)1 (0.3–5)0.62 (0.53–0.71)
Z-FEF75%≤ -2.013 (4–28)92 (85–97)2 (0.7–4)0.68 (0.59–0.76)
Z-FEF25–75%≤ -2.010 (3–25)92 (85–97)2 (0.7–4)0.65 (0.56–0.73)
Z-DL,CO/VA≤ -2.026 (13–43)98 (90–100)14 (8–23)0.78 (0.68–0.86)

  • Data are presented as quantity or quantity (95% CI). +LR: positive likelihood ratio; AUC: area under the curve; Z: Z-score; FVC: forced vital capacity; FEV0.5: forced expiratory volume in 0.5 s; FEF50%: forced expiratory flow at 50% of FVC; FEF75%: forced expiratory flow at 75% of FVC; FEF25–75%: forced expiratory flow at 25–75% of FVC; DL,CO: diffusing capacity of the lung for carbon monoxide; VA: alveolar volume.