| Variable | Univariate model | Multivariate model 1 | Multivariate model 2 | |||
| β±se | p-value | β±se | p-value | β±se | p-value | |
| WHO functional class | ||||||
| I | Ref. | <0.001 | Ref. | 0.08 | Ref. | 0.08 |
| II | -12.0±4.9 | -9.3±5.0 | -9.0±4.9 | |||
| III | -18.0±4.8 | -12.4±5.5 | -11.6±5.4 | |||
| IV | -32.4±5.9 | -21.5±8.1 | -20.7±7.9 | |||
| 6MWD per 10 m | 0.3±0.1 | 0.002 | <0.1±0.1 | 0.46 | -0.1±0.1 | 0.41 |
| BDI per 1 point | -2.6±0.5 | <0.001 | -1.0±0.7 | 0.16 | -0.8±0.7 | 0.27 |
| AQ20 per 1 sd | -4.7±1.1 | <0.001 | -3.0±1.2 | 0.02 | ||
| LHFQ per 1 sd | -5.4±1.1 | <0.001 | -3.8±1.3 | 0.004 | ||
#: measured using the physical component summary of the 36-item Short Form Health Survey at follow-up (median 12.3 m). The adjusted models included all variables shown in addition to age, sex, race, aetiology and class of therapy. Multivariate model 1: R2=0.34 (p<0.001); multivariate model 2: R2=0.36 (p<0.001). WHO: World Health Organization; 6MWD: 6-min walking distance; BDI: Borg dyspnoea index; AQ20: Airways Questionnaire 20; LHFQ: Living with Heart Failure Questionnaire; ref.: reference.