Table 1– Clinical details of patients whose initial epithelial brush biopsies suggested an isolated inner dynein arm defect or an inner dynein arm defect associated with a radial spoke defect

Patient	Suspected diagnosis on initial sample	Age yrs	Neonatal respiratory distress	Nasal symptoms	Cough	Ear problems	Situs inversus	NO ppb	CT-confirmed bronchiectasis
1	Inner dynein arm defect	3	Nil	Rhinorrhoea from birth	Continuous wet cough from birth	Glue ear and grommets	Nil	107 ppb (at age 5 yrs)	Not done
2	Inner dynein arm defect	15	Nil	Rhinorrhoea first year	Continuous wet cough from first year	Nil	Nil	Technical failure	Yes
3	Inner dynein arm defect	6	Nil	Rhinorrhoea from birth	Intermittent wet cough	Glue ear (right nasal polyp)	Nil	180 ppb	Not done
4	Radial spoke defect	7	Nil	Intermittent rhinorrhoea	Continuous wet cough from first year	Nil	Nil	342 ppb	Yes
5	Inner dynein arm defect	3	Nil	Rhinorrhoea from birth	Continuous wet cough from birth	Nil	Nil	Too young	Not done
6	Inner dynein arm defect	2	Nil	Rhinorrhoea from birth	Continuous wet cough from birth	Nil	Nil	Too young	Not done

NO: nitric oxide; ppb: parts per billion; CT: computed tomography.