Number of variables in model | Best model | Mean CV consistency | Mean prediction error % | pperm# | OR (95% CI)¶ | p-value | |
Gene(s) and/or environmental factors | SNP(s) | ||||||
Total IgE age 1-2 yrs | |||||||
1 | Siblings | 8.2 | 0.44 | 0.004 | 2.3 (1.6–3.3) | 0.000008 | |
2 | Siblings, TLR6 | rs1039559 | 2.6 | 0.45 | 0.04 | 4.6 (2.1–9.7) | 0.00008 |
3 | Day-care, Siblings, LBP | rs2232596 | 3.0 | 0.43 | 0.007 | NA+ | |
Total IgE 6–8 yrs | |||||||
1 | LBP | rs745144 | 4.6 | 0.46 | 0.13 | 1.3 (1.0–1.7) | 0.07 |
2 | TLR10, LY96 (MD2) | rs11096957, rs7838114 | 2.0 | 0.42 | 0.03 | 0.4 (0.2–0.6) | 0.0006 |
3 | Siblings, CD14, LBP | rs2915863, rs745144 | 2.4 | 0.45 | 0.03 | NA+ | |
Specific IgE to indoor allergens 6–8 yrs | |||||||
1 | TLR1 | rs5743604 | 4.2 | 0.45 | 0.04 | 0.6 (0.5–0.9) | 0.005 |
2 | TLR6, TLR6 | rs5743798, rs5743810 | 4.4 | 0.45 | 0.08 | 0.7 (0.3–1.5) | 0.5 |
3 | TLR1, LBP, TLR5 | rs5743594, rs6025085, rs851186 | 4.2 | 0.40 | 0.02 | NA+ |
SNP: single-nucleotide polymorphism; CV: cross validation; Ig: immunoglobulin; LBP: lipopolysaccharide-binding protein; NA: not available. #: significance of prediction error (empirical p-value based on 1,000 permutations); ¶: after logistic regression with no or one older sibling and/or wild-type genotype in a recessive model used as the reference category; +: logistic regression was not performed on three-factor interactions.