Indacaterol | Tiotropium | |
Plasma potassium <3.0 mmol·L−1 | 0/778 | 0/776 |
Blood glucose >9.99 mmol·L−1 | 26/778 (3.3) | 20/776 (2.6) |
High pulse rate# | 2/792 (0.3) | 0/799 |
High systolic blood pressure¶ | 7/792 (0.9) | 5/799 (0.6) |
High diastolic blood pressure+ | 6/792 (0.8) | 13/799 (1.6) |
QTc interval | ||
Absolute value males/females >450/470 ms | 23/793 (2.9) | 25/799 (3.1) |
Absolute value >500 ms | 0/793 | 1/799 (0.1) |
Increase 30–60 ms | 36/788 (4.6) | 48/794 (6.0) |
Increase >60 ms | 2/788 (0.3) | 0/794 |
Data are presented as n/N (%). #: >130 bpm, or ≥120 bpm and ≥15 bpm increase from baseline; ¶: >200 mmHg, or ≥180 mmHg and ≥20 mmHg increase from baseline; +: >115 mmHg, or ≥105 mmHg and ≥15 mmHg increase from baseline.