Sham | MI | Bos100 | Bos200 | |
Cardiac output mL·min−1 | 140±5 | 120±11 | 119±13 | 114±7 |
LV wall motion abnormality % | 0 | 45±4# | 48±3# | 42±5# |
LV wall motion score index | 1.00±0 | 1.96±0.05# | 2.00±0.07# | 1.87±0.07# |
LV end-diastolic dimension mm | 7.6±0.2 | 10.9±0.2# | 10.9±0.2# | 11.2±0.2# |
LV end-systolic dimension mm | 3.7±0.2 | 9.3±0.2# | 9.3±0.3# | 9.5±0.3# |
LV end-diastolic area mm2 | 48.3±2.2 | 91.1±2.6# | 94.6±4.7# | 96.7±4.1# |
LV end-systolic area mm2 | 16.0±1.4 | 62.4±2.9# | 68.5±4.7# | 65.3±3.6# |
RVDd mm | 3.5±0.1 | 3.5±0.1 | 3.6±0.2 | 3.6±0.1 |
RVET ms | 83.4±2.5 | 83.6±2.9 | 86.4±1.8 | 80.7±2.3 |
TVc-o | 97.1±4.1 | 120.1±5.1** | 127.9±8.1** | 113.9±5.4 |
Data are presented as mean±sem. MI: myocardial infarction; Bos100: bosentan 100 mg·kg−1·day−1; Bos200: bosentan 200 mg·kg−1·day−1; LV: left ventricular; RVDd: right ventricular end-diastolic dimension; RVET: right ventricular ejection time; TVc-o: tricuspid valve closing to opening. **p<0.01 versus sham; #: p<0.0001 versus sham.