Table 1– Description of the population according to asthma status before hire
AllAsthma before hirep-value
NoYes
Subjects298123175
Baseline data in childhood at EGEA1
 Males158 (53.0)52 (42.3)106 (60.6)0.002
 Status in the study
  Cases89 (29.9)82 (50.9)
  Siblings152 (51.0)80 (65.0)72 (41.1)
  Control57 (19.1)43 (35.0)14 (8.0)
 Asthmatic at baseline150 (50.5)150 (85.7)
 Asthma severity#
  Mild97 (37.6)97 (72.4)
  Moderate-to-severe37 (14.4)37 (27.6)
 Symptom score
  0124 (45.1)102 (87.9)22 (13.8)
  1 to 394 (34.2)14 (12.1)80 (50.3)<0.001
  4 to 557 (20.7)057 (35.9)
 FEV1 % pred98.6±12.199.5±10.698.0±13.10.27
 Methacholine challenge223103120
 BHR log slope5.40±2.516.80±2.504.21±1.79<0.001
 Positive SPT
  No102 (34.9)73 (60.3)29 (17.0)<0.001
  Yes190 (65.1)48 (39.7)142 (83.0)
 IgE IU·mL−1 geometric mean (95% CI)149 (122–181)52 (39–70)312 (254–382)<0.001
 Allergic rhinitis103 (34.7)12 (9.8)91 (52.3)<0.001
Follow-up data at EGEA2
 Age at follow-up yrs23.9±2.524.7±2.523.6±2.40.01
 Age at the first hire yrs19.8±2.420.2±2.319.6±2.40.02
 University diploma level180 (60.4)81 (65.9)99 (56.6)0.11
 Current smoker at the age of first employment137 (46.0)57 (46.3)80 (45.7)0.91
 Parental asthma153 (51.3)51 (41.5)102 (58.3)0.004
 Asthma attacks the year before the first employment
  No83 (29.0)83 (50.9)
  Yes80 (28.0)80 (49.1)
  • Data are presented as n, n (%) or mean±sd, unless otherwise stated. EGEA: Epidemiological Study on the Genetics and Environment of Asthma; FEV1: forced expiratory volume in 1 s; % pred: % predicted; BHR: bronchial hyperresponsiveness; SPT: skin-prick test; Ig: immunoglobulin. #: asthma severity was recorded only among the 150 subjects with asthma at baseline, and was missing for 16 of them.