Prediction of mortality | Prediction of any adverse outcomes | Prediction of ICU admission | Prediction of complications | |||||||||
AUC (95% CI) | p-value versus PSI | p-value versus CURB-65 | AUC (95% CI) | p-value versus PSI | p-value versus CURB-65 | AUC (95% CI) | p-value versus PSI | p-value versus CURB-65 | AUC (95% CI) | p-value versus PSI | p-value versus CURB-65 | |
PSI score | 0.79 (0.75–0.84) | 0.008 | 0.67 (0.62–0.71) | 0.26 | 0.65 (0.59–0.71) | 0.7 | 0.50 (0.40–0.60) | 0.93 | ||||
CURB-65 score | 0.72 (0.65–0.78) | 0.008 | 0.64 (0.60–0.69) | 0.26 | 0.64 (0.58–0.70) | 0.70 | 0.50 (0.41–0.60) | 0.93 | ||||
Initial PCT levels | 0.60 (0.52–0.67) | <0.001 | <0.01 | 0.66 (0.61–0.71) | 0.82 | 0.63 | 0.69 (0.64–0.75) | 0.27 | 0.14 | 0.69 (0.58–0.77) | <0.01 | <0.01 |
Peak PCT levels | 0.65 (0.57–0.72) | <0.01 | 0.13 | 0.69 (0.65–0.74) | 0.40 | 0.1 | 0.73 (0.67–0.79) | 0.035 | 0.01 | 0.7 (0.59–0.80) | <0.01 | <0.01 |
Combined initial PCT/PSI score | 0.80 (0.74–0.85) | 0.91 | 0.71 (0.66–0.76) | <0.01 | 0.72 (0.67–0.78) | <0.01 | 0.68 (0.58–0.77) | <0.01 | ||||
Combined initial PCT/CURB-65 score | 0.73 (0.66–0.79) | 0.43 | 0.70 (0.65–0.75) | 0.008 | 0.71 (0.65–0.77) | <0.01 | 0.68 (0.58–0.78) | <0.01 |
ICU: intensive care unit; AUC: area under the ROC curve; PSI: Pneumonia Severity Index;; CURB-65: confusion, urea >7 mmol·L−1, respiratory frequency ≥30 breaths·min−1, low blood pressure (systolic value <90 mmHg or diastolic value ≤60 mmHg) and age ≥65 yrs; PCT: procalcitonin.