Table 4– Genotype frequencies for the rs2202507 glycophorin A single-nucleotide polymorphism in chronic obstructive pulmonary disease (COPD) and lung cancer (LC) (total and subgrouped by pre-operative lung function) cohorts compared with smoking controls

	Subjects	A	C	OR (95% CI)^#	p-value^#	AA	AC	CC	OR (95% CI)^¶	p-value^¶
Primary cohorts
Controls	480 (99)	489 (51)	471 (49)			138 (29)	213 (44)	129 (27)
COPD	457 (99)	505 (55)	409 (45)	0.84 (0.70–1.01)	0.061	136 (30)	233 (51)	88 (19)	0.65 (0.47–0.89)	0.006
LC	439 (97)	465 (53)	413 (47)	0.92 (0.76–1.11)	0.385	116 (26)	233 (53)	90 (21)	0.70 (0.51–0.97)	0.023
LC subgroup analyses
LC with COPD	212	231 (54)	193 (46)	0.87 (0.69–1.10)	0.224	62 (29)	107 (50)	43 (20)	0.69 (0.46–1.04)	0.065
LC only	204	217 (53)	191 (47)	0.91 (0.72–1.16)	0.446	52 (25)	113 (55)	39 (19)	0.64 (0.42–0.98)	0.031
COPD subgroup analysis
COPD and LC with COPD	669	736 (55)	602 (45)	0.85 (0.72–1.01)	0.053	198 (30)	340 (51)	131 (20)	0.66 (0.50–0.88)	0.004

Data are presented as n or n (call rate %), unless otherwise stated. ^#: C versus A compared with matched smoking controls (Mantel–Haenszel); ^¶: CC versus AC/AA compared with matched smoking controls (Mantel–Haenszel).