Table 1– Bioelectric properties of freshly excised native tracheal and bronchial tissues
Mice nBaselineAmiloridePost-amilorideIBMX/ForskolinUTP
Vte mVIsc μA·cm−2Rte ω·cm2ΔIsc μA·cm−2% basal IscIsc μA·cm−2% basal IscΔIsc μA·cm−2% basal IscΔIsc μA·cm−2% basal Isc
Trachea27-2.1±0.3-135.4±15.418.6±2.9103.6±11.277.4±1.8-31.8±5.122.6±1.8-165.2±22.7124.7±8.6-204.0±19.5163.5±13.4
Bronchus20-1.1±0.2**-36.9±4.4***24.6±3.232.7±3.8***91.8±4.6**-4.5±1.7***8.2±4.4**-85.9±7.6**267.1±36.0***-45.8±7.1***118.1±14.2*
  • Data are presented as mean±sem, unless otherwise stated. Summary of basal bioelectric properties (transepitherlial voltage (Vte), transepithelial resistance (Rte) and short-circuit current (Isc)) and effects of amiloride, cyclic adenosine 5′-monophosphate-dependent activation and uridine 5′-triphosphate (UTP)-induced activation on transepithelial Isc in freshly excised tracheal and bronchial tissues from vehicle-treated wild-type mice. Responses are expressed as absolute change in IscIsc) and as percentage of basal Isc (% Isc). IBMX: 3-isobutyl-1-methylxanthine. *: p<0.05 compared with tracheal tissues; **: p<0.01 compared with tracheal tissues; ***: p<0.001 compared with tracheal tissues.