| 48 h | 96 h | |||||
| WT | Heterozygous FVL | Homozygous FVL | WT | Heterozygous FVL | Homozygous FVL | |
| Mice n | 8 | 8 | 8 | 8 | 8 | 8 |
| MPO ng·mL−1 | 9.3 (6.7–10) | 8.0 (7.1–8.8) | 9.1 (7.1–9.8) | 14 (12–17) | 14 (12–17) | 14 (12–15) |
| TNF-α pg·mL−1 | 317 (196–423) | 183 (171–250) | 121 (127–262)* | 344 (190–433) | 420 (376–577) | 503 (352–770) |
| IL-6 ng·mL−1 | 2.6 (1.7–6.1) | 1.5 (1.2–1.9) | 1.9 (1.1–2.2) | 1.6 (0.8–2.3) | 3.2 (1.7–4.8) | 2.0 (1.7–5.3) |
| IL-12 pg·mL−1 | ND | ND | ND | 5.0 (5.0–12) | 10 (5.0–35) | 8.8 (5.0–33) |
| MCP-1 ng·mL−1 | 8.9 (5.8–10) | 5.4 (5.2–6.4) | 5.8 (5.3–7.5) | 10 (5.8–10) | 10 (10–10) | 10 (9.1–10) |
| IL-10 pg·mL−1 | 749 (500–1058) | 281 (185–335)** | 424 (130–882) | 244 (210–426) | 343 (187–1401) | 534 (360–577) |
| IFN-γ pg·mL−1 | 46 (29–79) | 44 (34–50) | 24 (14–45) | 7.6 (12–17) | 31 (16–56)* | 14 (9.5–32) |
| KC pg·mL−1 | 941 (622–1297) | 753 (522–906) | 673 (615–1025) | 1090 (770–1334) | 941 (759–1256) | 675 (559–892) |
Data are presented as median (interquartile range) unless otherwise stated. WT: wild-type; FVL: factor V Leiden; TNF: tumour necrosis factor; IL: interleukin; MCP: monocyte chemotactic protein; IFN: interferon; KC: keratinocyte-derived chemokine; ND: not detected. *: p<0.05 compared to wild-type; **: p<0.01 compared to wild-type.