| Variables | Normoxia | Acute hypoxia# | ||
| Placebo | Sitaxsentan | Placebo | Sitaxsentan | |
| LL score | 2±0.5 | 4±1.5 | ||
| Sp,O2 % | 98±0.3 | 98±0.2 | 72±2¶ | 73±3¶ |
| BP mmHg | 87±2 | 82±2+ | 83±2 | 81±2 |
| HR beats·min−1 | 57±3 | 60±4 | 69±5§ | 69±5§ |
| Q L·min−1 | 4.7±0.3 | 5.0±0.4 | 6.2±0.5§ | 6.6±0.6§ |
| Systolic Ppa mmHg | 23±1 | 23±2 | 37±2¶ | 28±2§,ƒ |
| P̄pa mmHg | 16±1 | 16±1 | 25±2¶ | 19±1§,ƒ |
| PVR mmHg·L−1·min−1 | 3.5±0.2 | 3.4±0.3 | 4.2±0.3§ | 3.1±0.3ƒ |
| Tei index | 0.21±0.05 | 0.18±0.03 | 0.30±0.05 | 0.19±0.03+ |
| TAPSE cm | 3.1±0.2 | 3.1±0.1 | 3.0±0.1 | 3.0±0.1 |
Data are presented as mean±se. LL: Lake Louise; Sp,O2: arterial oxygen saturation measured by pulse oximetry; BP: blood pressure; HR: Heart rate; Q: cardiac output; Ppa: pulmonary artery pressure; P̄pa: mean Ppa; PVR: pulmonary vascular resistance; TAPSE: tricuspid annular plane systolic excursion. #: hypoxia is defined as fraction of inspired oxygen (FI,O2) 0.12. ¶: p<0.001, hypoxia versus normoxia with same drug; +: p<0.05, hypoxia versus normoxia with same drug; §: p<0.05, sitaxsentan versus placebo at same FI,O2; ƒ: p<0.001, sitaxsentan versus placebo at same FI,O2.