Table 2– Univariate analysis of individuals’ variables at baseline comparing mean values and/or proportion of patients according to whether or not (yes or no, respectively) an improvement larger than the mimimum clinically important difference (MCID) was seen in each pulmonary rehabilitation outcome

	Variable (MCID)
	6MWD (+54 m)			MRC score (-1 point)			SGRQ score (-4 points)
	Yes	No	p-value	Yes	No	p-value	Yes	No	p-value
Age yrs	67.2±7.6	68.2±7.4	0.072	68.2±7.8	68.0±7.2	0.808	68.1±7.6	68.8±6.9	0.524
Males/females n	107/35	123/42	0.871	158/60	69/:20	0.162	149/57	65/36	0.753
BMI kg·m⁻²	27.5±4.7	26.8±5.6	0.283	27.6±5.6	26.6±4.0	0.158	26.7±3.7	26.2±4.3	0.400
FEV₁ % pred	49.3±13.0	49.8±14.9	0.755	49.0±14.5	51.0±13.0	0.294	49.4±14.1	48.7±17.1	0.730
Charlson score	2.58±1.3	2.73±1.1	0.340	2.66±1.2	2.65±1.1	0.979	2.56±1.0	2.75±1.4	0.375
P_a,O₂ mmHg	71.4±9.6	72.3±9.9	0.459	72.0±10.1	71.0±8.9	0.456	71.3±9.8	74.9±10.1	0.012
P_a,CO₂ mmHg	41.8±5.6	41.0±5.2	0.213	42.0±5.7	40.3±4.4	0.025	42.0±5.3	40.6±5.3	0.061
Baseline 6MWD	372.3±85.9	418.0±73.4	0.001	389.5±77.9	421.8±75.8	0.001	406.4±73.6	396.7±81.2	0.356
Baseline MRC	3.22±0.8	3.20±0.8	0.827	3.55±0.6	2.36±0.6	0.001	3.21±0.8	3.33±0.9	0.311
Baseline SGRQ	42.8±16.4	42.6±15.4	0.935	42.8±15.6	41.0±16.2	0.408	44.5±15.5	38.3±15.9	0.005
Comorbidities
Single
Chronic Heart Failure	12 (40)	18 (60)	0.470	11 (34)	19 (62)	0.336	21 (70)	9 (30)	0.177
Diabetes	21 (51)	20 (49)	0.493	14 (34)	27 (66)	0.490	26 (63)	15 (37)	0.711
Hypertension	57 (48)	62 (52)	0.646	32 (27)	87 (73)	0.265	75 (63)	44 (37)	0.497
Coronary disease	14 (38)	23 (62)	0.274	26 (70)	11 (30)	0.542	19 (51)	18 (49)	0.709
Dyslipidaemia	23 (51)	22 (49)	0.479	27 (60)	18 (40)	0.570	28 (62)	17 (38)	0.537
Osteoporosis	7 (24)	22 (76)	0.012	16 (55)	13 (45)	0.964	18 (62)	11 (38)	0.256
Other diseases	15 (41)	22 (59)	0.733	24 (65)	13 (35)	0.450	27 (73)	10 (27)	0.046
Aggregated
Heart disease	24 (40)	36 (60)	0.279	37 (62)	23 (38)	0.425	39 (65)	21 (35)	0.677
Metabolic disease	73 (46)	85 (54)	0.985	118 (75)	40 (25)	0.069	103 (65)	55 (35)	0.606
Skeletal disease	7 (24)	22 (76)	0.012	16 (55)	13 (45)	0.964	18 (62)	11 (38)	0.256
Comorbid categories
0	57 (49)	60 (51)	0.497	71 (61)	46 (39)	0.016	88 (75)	29 (25)	0.365
1	48 (45)	58 (55)	0.804	89 (84)	17 (16)	0.000	70 (66)	47 (44)	0.073
≥2	37 (44)	47 (56)	0.634	59 (70)	25 (30)	0.205	60 (71)	24 (29)	0.239

Data are presented as mean±sd or n (%), unless otherwise stated. 6MWD: 6-min walk distance; MRC: Medical Research Council dyspnoea scale; SGRQ: St George’s Respiratory Questionnaire; BMI: body mass index; FEV₁: forced expiratory volume in 1 s; % pred: % predicted; P_a,O₂: arterial oxygen tension; P_a,CO₂: arterial carbon dioxide tension. Bold indicates statistically significant p-values.