Body mass index kg·m−2 | |||||
<22.5 | 22.5–24.9 | 25.0–29.9 | 30.0–34.9 | ≥35 | |
Males | |||||
Incidence rate per 1,000 person-yrs | 5.2 | 3.6 | 3.9 | 5.4 | 7.0 |
Overall HR (95% CI) | |||||
Crude# | 1.5 (1.2–1.8) | 1.0 (ref.) | 1.1 (0.9–1.2) | 1.5 (1.2–1.8) | 2.1 (1.5–3.0) |
Adjusted¶ | 1.4 (1.1–1.7) | 1.0 (ref.) | 1.1 (0.9–1.3) | 1.4 (1.2–1.7) | 2.0 (1.4–2.8) |
Adjusted+ | 1.4 (1.1–1.7) | 1.0 (ref.) | 1.0 (0.8–1.1) | 1.0 (0.8–1.3) | 1.2 (0.8–1.7) |
HR (95% CI) by subgroup¶ | |||||
Age yrs | |||||
50–54 | 1.3 (0.8–1.9) | 1.0 (ref.) | 1.0 (0.8–1.4) | 1.6 (1.1–2.3) | 1.4 (0.7–2.9) |
55–59 | 1.2 (0.8–1.7) | 1.0 (ref.) | 0.8 (0.6–1.1) | 1.2 (0.9–1.7) | 2.0 (1.2–3.5) |
≥60 | 1.7 (1.2–2.4) | 1.0 (ref.) | 1.4 (1.1–1.7) | 1.5 (1.1–2.1) | 2.3 (1.3–4.3) |
Smoking status§ | |||||
Nonsmokers | 1.0 (0.6–1.4) | 1.0 (ref.) | 1.1 (0.9–1.4) | 1.6 (1.2–2.2) | 2.6 (1.6–4.1) |
Current smokers | 1.6 (1.2–2.1) | 1.0 (ref.) | 1.1 (0.9–1.3) | 1.3 (1.0–1.7) | 1.3 (0.7–2.4) |
Females | |||||
Incidence rate per 1,000 person-yrs | 4.0 | 3.4 | 3.0 | 2.9 | 4.3 |
Overall HR (95% CI) | |||||
Crude# | 1.3 (1.1–1.5) | 1.0 (ref.) | 0.8 (0.7–1.0) | 0.8 (0.6–1.0) | 1.2 (0.8–1.6) |
Adjusted¶ | 1.2 (1.0–1.4) | 1.0 (ref.) | 0.9 (0.7–1.0) | 0.8 (0.6–1.0) | 1.2 (0.8–1.6) |
Adjusted+ | 1.2 (1.0–1.4) | 1.0 (ref.) | 0.8 (0.7–1.0) | 0.7 (0.6–0.9) | 0.8 (0.6–1.1) |
HR (95% CI) by subgroup¶ | |||||
Age yrs | |||||
50–54 | 1.3 (0.9–1.8) | 1.0 (ref.) | 0.8 (0.6–1.2) | 0.9 (0.6–1.5) | 1.1 (0.5–2.4) |
55–59 | 1.2 (0.9–1.6) | 1.0 (ref.) | 0.9 (0.7–1.2) | 0.8 (0.5–1.2) | 1.3 (0.8–2.4) |
≥60 | 1.2 (0.9–1.5) | 1.0 (ref.) | 0.8 (0.7–1.1) | 0.8 (0.6–1.2) | 1.1 (0.7–1.8) |
Smoking status§ | |||||
Nonsmokers | 1.0 (0.8–1.3) | 1.0 (ref.) | 0.8 (0.6–1.0) | 0.7 (0.5–1.0) | 1.4 (0.9–2.0) |
Current smokers | 1.3 (1.1–1.7) | 1.0 (ref.) | 1.0 (0.8–1.2) | 1.1 (0.8–1.5) | 1.0 (0.5–1.7) |
#: the crude HR was calculated with the use of Cox's regression, with age as the underlying time variable; ¶: multivariable-adjusted model was based on the crude model with additional adjustment for smoking status, alcohol intake, schooling and educational level; +: multivariable-adjusted model as specified above and with additional adjustment for other major chronic diseases diagnosed during follow-up; §: HRs in strata of smoking status were not adjusted for smoking status.