Table 1– Predicted number of failures and respective drug resistance pattern of failures during standardised initial treatment followed by standardised retreatment (hypothetical cohorts of 1,000 new cases in each country start initial therapy with one of two standardised regimens)
CountryInitial treatmentRetreatment
Initial regimenPatients who fail# nDrug resistance patternPatients who fail nDrug resistance pattern
Pan-sensitive %Resistance %MDR-TB %Pan-sensitive %Resistance %MDR-TB %
Dominican Republic2HRZE/6HE6614356260298
2HRZE/4HR4224942600100
Peru2HRZE/6HE3034354111397
2HRZE/4HR195887110199
Vietnam2HRZE/6HE462742491892
2HRZE/4HR174138290199
UR Tanzania2HRZE/6HE912543433691
2HRZE/4HR716206431297
Nicaragua2HRZE/6HE138692333989
2HRZE/4HR714206631297
Gambia2HRZE/6HE620354524592
2HRZE/4HR618216121297
Kenya2HRZE/6HE8148241102565
2HRZE/4HR522285012494
  • Cases that died while on treatment were excluded from the calculations. MDR: multidrug-resistance; TB: tuberculosis; 2HRZE: isoniazid, rifampin, pyrazinamide and ethambutol for 2 months; 6HE; isoniazid plus ethambutol for 6 months; 4HR: isoniazid plus rifampin for 4 months. #: and start retreatment; : except MDR.