Characteristic | Hazard ratio (95% CI) | p-value |
Sex | ||
Female | 1.0 | |
Male | 1.10 (0.73–1.65) | 0.64 |
Employment | ||
Employed | 1.0 | |
Unemployed | 1.78 (0.91–3.48) | 0.09 |
Retired/student | 2.56 (1.28–5.12) | 0.008 |
Category of MDR-TB | ||
Never treated for TB | 1.0 | |
Age previously treated for TB yrs | ||
<35 | 1.27 (0.71–2.27) | 0.41 |
35–54 | 1.14 (0.75–1.75) | 0.54 |
≥55 | 1.67 (0.97–2.88) | 0.07 |
Age previously treated for MDR-TB yrs | ||
<35 | 1.55 (0.67–3.59) | 0.31 |
35–54 | 1.66 (0.94–2.94) | 0.08 |
≥55 | 4.34 (1.62–11.6) | 0.003 |
Cavitation on radiography | ||
No cavitation | 1.0 | |
Unilateral cavitation | 1.22 (0.78–1.92) | 0.39 |
Bilateral cavitation | 1.90 (1.19–3.03) | 0.007 |
Presence of XDR-TB in initial isolate | ||
No | 1.0 | |
Yes | 1.96 (1.14–3.36) | 0.02 |
Culture conversion | ||
Began treatment culture-negative | 1.0 | |
Conversion before 62 days of treatment | ||
Treatment time ≤100 days | 0.88 (0.25–3.03) | 0.84 |
Treatment time >100 days | 0.51 (0.20–1.29) | 0.16 |
Conversion after 62 days of treatment | ||
Treatment time ≤100 days | 0.75 (0.23–2.41) | 0.63 |
Treatment time >100 days | 3.83 (1.81–8.12) | 0.0005 |
Drugs used in regimen for ≥3 months | ||
Kanamycin | 0.60 (0.43–0.83) | 0.002 |
Ofloxacin | 0.54 (0.30–0.97) | 0.04 |
Prothionamide | 0.64 (0.45–0.90) | 0.01 |
Cycloserine | 0.40 (0.25–0.64) | <0.001 |
XDR-TB: extensively drug-resistant TB.