Table 7– Time-dependent Cox proportional hazards multivariable model for poor outcome among 994 multidrug-resistant tuberculosis (MDR-TB) patients, Latvia, 2000–2004
CharacteristicHazard ratio (95% CI)p-value
Sex
 Female1.0
 Male1.10 (0.73–1.65)0.64
Employment
 Employed1.0
 Unemployed1.78 (0.91–3.48)0.09
 Retired/student2.56 (1.28–5.12)0.008
Category of MDR-TB
 Never treated for TB1.0
 Age previously treated for TB yrs
  <351.27 (0.71–2.27)0.41
  35–541.14 (0.75–1.75)0.54
  ≥551.67 (0.97–2.88)0.07
 Age previously treated for MDR-TB yrs
  <351.55 (0.67–3.59)0.31
  35–541.66 (0.94–2.94)0.08
  ≥554.34 (1.62–11.6)0.003
Cavitation on radiography
 No cavitation1.0
 Unilateral cavitation1.22 (0.78–1.92)0.39
 Bilateral cavitation1.90 (1.19–3.03)0.007
Presence of XDR-TB in initial isolate
 No1.0
 Yes1.96 (1.14–3.36)0.02
Culture conversion
 Began treatment culture-negative1.0
 Conversion before 62 days of treatment
  Treatment time ≤100 days0.88 (0.25–3.03)0.84
  Treatment time >100 days0.51 (0.20–1.29)0.16
 Conversion after 62 days of treatment
  Treatment time ≤100 days0.75 (0.23–2.41)0.63
  Treatment time >100 days3.83 (1.81–8.12)0.0005
Drugs used in regimen for ≥3 months
 Kanamycin0.60 (0.43–0.83)0.002
 Ofloxacin0.54 (0.30–0.97)0.04
 Prothionamide0.64 (0.45–0.90)0.01
 Cycloserine0.40 (0.25–0.64)<0.001
  • XDR-TB: extensively drug-resistant TB.