Patient 1 | Patient 2 | |
Age at diagnosis of emphysema yr | 71 | 59 |
Sex | Female | Female |
BMI kg·m-2 | 18 | 18 |
Smoking | Never | Never |
Inhaled toxics | None | None |
FEV1 L (% pred)# | 0.810 (39) | 1.640 (67) |
FVC L (% pred)# | 2.540 (97) | 3.580 (125) |
FEV1/FVC# | 31.9 | 45.8 |
TLC L (% pred) | 4.448 (94) | 6.800 (133) |
RV L (% pred) | 1.910 (91) | 3.190 (165) |
Pa,O2mmHg | 68 | 79 |
Pa,CO2 mmHg | 36 | 32 |
CT scan | Centrilobular and panlobular emphysema mild bronchiectasis | Centrilobular and bullous emphysema |
Serum α1-antitrypsin | 1.35 g·L−1 | 1.98 g·L−1 |
Protease inhibitor phenotype | Pi MM | Pi MS |
Duodenal biopsy | Subtotal villous atrophy | Total villous atrophy |
IgG anti-gliadin U·mL−1 | 23 | 62 |
IgA anti-gliadin U·mL−1 | >150 | 114 |
IgG anti-transglutaminase | + | 20 |
IgA anti-transglutaminase | + | >120 |
Haemoglobin g·dL−1 | 13.2 | 10.8 |
Mean corpuscular volume μm3 | 93 | 74 |
Ferritin ng·mL−1 | 154 | 3 |
25 hydroxy vitamin D3 ng·mL−1 | 15 | 12 |
BMI: body mass index; FEV1: forced expiratory volume in 1 s; % pred: % predicted; FVC: forced vital capacity; TLC: total lung capacity; RV: residual volume; Pa,O2: arterial oxygen tension; Pa,CO2: arterial carbon dioxide tension; CT; computed tomography; Ig; immunoglobulin. #: results are presented as post-bronchodilator data.