| Non-XDR-TB | XDR-TB | p-value | |
| Cases n | 979 | 48 | |
| Demographic characteristic | |||
| Sex | |||
| Male | 746 (76.2) | 34 (70.8) | 0.40 |
| Female | 233 (23.8) | 14 (29.2) | Ref |
| Age group yrs | |||
| <18 | 7 (0.8) | 1 (2.1) | |
| 18–24 | 66 (6.7) | 6 (12.5) | |
| 25–34 | 206 (21.0) | 8 (16.7) | |
| 35–44 | 284 (29.0) | 17 (35.4) | |
| 45–54 | 240 (24.5) | 13 (27.0) | |
| >55 | 176 (18.0) | 3 (6.3) | |
| Age yrs | |||
| <45 | 563 (57.5) | 32 (66.7) | 0.21 |
| >45 | 416 (42.5) | 16 (32.3) | Ref |
| Location | |||
| Riga, Latvia | 333 (34.0) | 22 (45.8) | 0.09 |
| Other | 646 (66.0) | 26 (54.2) | Ref |
| Birthplace | |||
| Latvia | 859 (87.7) | 40 (83.3) | 0.37 |
| Other | 120 (12.3) | 8 (16.7) | Ref |
| Housing | |||
| Tenant | 212 (21.6) | 13 (27.1) | 0.37 |
| Owner | 767 (78.4) | 35 (72.9) | Ref |
| Employment | |||
| Student/retired | 270 (27.6) | 18 (37.5) | 0.14 |
| Unemployed | 547 (55.9) | 26 (54.2) | 0.81 |
| Employed | 162 (16.5) | 4 (8.3) | Ref |
| Living situation | |||
| With ≥2 persons | 362 (37.0) | 19 (39.5) | 0.48 |
| With 1 person | 292 (29.8) | 12 (25.0) | 0.61 |
| Alone | 210 (21.4) | 9 (18.8) | Ref |
| Missing | 115 (11.8) | 8 (16.7) | |
| History of incarceration | |||
| None | 665 (68.0) | 30 (62.5) | 0.43 |
| Any | 313 (32.0) | 18 (37.5) | Ref |
| Unknown | 1 (0.1) | ||
| Past/current heavy alcohol use | |||
| None | 432 (44.1) | 17 (35.4) | 0.23 |
| Ever | 547 (55.9) | 31 (64.6) | Ref |
| Injection drug use ever | |||
| No | 907 (92.6) | 43 (89.5) | 0.58 |
| Yes | 45 (4.6) | 3 (6.3) | Ref |
| Unknown | 27 (2.8) | 2 (4.1) | |
| Started treatment while incarcerated | |||
| No | 904 (92.3) | 45 (93.8) | 0.72 |
| Yes | 75 (7.7) | 3 (6.2) | Ref |
| Clinical characteristics | |||
| BMI kg·m−2 | |||
| Males | 20.6 (19.0–22.3) | 21.1 (19.3–22.2) | 0.42§ |
| Females | 20.3 (18.6–22.5) | 19.7 (17.2–22.4) | 0.41§ |
| Males <18·5¶ | 137/728 (18.8) | 7/34 (20.6) | 0.79 |
| Females <18·5+ | 54/228 (23.6) | 4/14 (28.6) | 0.67 |
| HIV status | |||
| Infected | 29 (3.0) | 3 (6.2) | 0.2 |
| Uninfected | 945 (96.5) | 45 (93.8) | Ref |
| Unknown | 5 (0.5) | 0 (0) | |
| Category of MDR-TB | |||
| Previously treated for MDR | 100 (10.2) | 16 (33.3) | <0.001 |
| Previously treated for TB with only first-line drugs | 520 (53.1) | 12 (25.0) | <0.001 |
| Never treated for TB | 359 (36.7) | 20 (41.7) | Ref |
| Site of MDR-TB | |||
| Pulmonary and extrapulmonary | 57 (5.8) | 0 (0) | 0.08 |
| Pulmonary | 970 (94.2) | 48 (100) | Ref |
| Radiological findings at onset | |||
| Bilateral cavitary | 208 (21.3) | 15 (31.3) | 0.10 |
| Unilateral cavitary | 458 (46.8) | 23 (47.9) | 0.88 |
| Non-cavitary | 313 (31.9) | 10 (20.8) | Ref |
| Smear positive at treatment onset | 494 (51.2) | 32 (66.7) | 0.04 |
| Colony count of initial culture among positive | |||
| 3–4 | 413 (54.1) | 28 (65.1) | 0.16 |
| 1–2 | 351 (45.9) | 15 (34.9) | Ref |
| Drugs to which M. tuberculosis resistant at treatment onset | 5 (4–7) | 8 (7–9) | <0.001§ |
| at treatment initiation | |||
| 2–4 | 285 (29.1) | ||
| 5 | 229 (23.4) | ||
| 6 | 186 (19.0) | 6 (12.5) | |
| 7 | 127 (13.0) | 13 (27.1) | |
| 8 | 103 (10.5) | 10 (20.8) | |
| 9 | 45 (4.6) | 10 (20.8) | |
| 10 | 4 (0.4) | 9 (18.8) |
Data are presented as n (%) or median (interquartile range), unless otherwise stated. M. tuberculosis: Mycobacterium tuberculosis; Ref: reference. #: year 2000 for civilians only; ¶: 18 unknown; +: 5 unknown; §: Wilcoxon rank-sum test.