Table 1– Demographic, clinical, sleep and ventilatory response characteristics in narcoleptic (NC) versus control subjects
Subjects n130117
 Age yrs20.1±10.022.0±6.9
 Males %6962
 BMI kg·m−223.6±4.3***21.4±3.1
 BSA m21.73±0.341.70±0.24
 Onset age yrs12.3±6.5NA
 Illness duration yrs7.8±6.9NA
Symptoms at interview %
 Daytime sleepiness1000
 Typical cataplexy1000
Polysomnography study
 Sleep parameters
  Sleep efficiency %91.4±9.387.1±9.9#
  Sleep latency8.0±10.0***15.1±17.9#
  REM latency72.2±88.1**124.2.±66.1#
  % REM latency <20 min63 (48)***4 (7)
  Mean sleep latency3.7±2.1**16.0±3.4#
  Numbers of SOREMs4.4±0.8***0.5±0.9#
  % MSL ≤8 min, SOREM ≥2127 (97.7)***0 (0)
 Sleep-disordered breathing
  AHI events·h−1 overall2.8±5.4**0.8±1.6#
  AHI >521 (16)***3 (5.3)
  AHI >155 (4)0 (0)
  Lowest O2 %86.7±6.7***90.9±4.1
  Mean O2 %96.3±1.096.2±1.0
  OSAI/AHI %34.5±36.5*17.4±29.1
  CSAI/AHI %1.8±8.82.4±6.2
  MSAI/AHI %6.8±46.17.8±23.9
  HI/AHI %60.6±36.875.4±37.0
  NREM AHI (events·h−1)2.3±5.2*0.5±1.4
  REM AHI (events·h−1)5.1±11.91.6±4.1
HLA-DQB1*0602 positive130 (100)***28 (22)
CSF Hcrt level pg·mL−118.8±1.70NA
  • Data are presented as mean±sd or n (%), unless otherwise stated. BMI: body mass index; BSA: body surface area; REM: rapid eye movement; MSLT: multiple sleep latency test; SOREM: sleep onset REM; MSL: mean sleep latency; AHI: apnoea hypopnoea index; OSAI: obstructive sleep apnoea index; CSAI: central sleep apnoea index; MSAI: mixed sleep apnoea index; HI: hypopnoea index; NREM: non-REM; CSF: cerebrospinal fluid; Hcrt: hypocretin. *: p<0 05. **: p<0.01. ***: p<0.001. #: n = 57. : n = 28% of the sample.