Table 6– Assessment of morning responsiveness to change according to Global Chest Symptoms Questionnaire (GCSQ) and peak expiratory flow (PEF) scores from pre- to post-dose
Subjects nMean changeESSRMt-statisticCorrelation r-value
Study 1
ΔGCSQ5296-0.18-0.27-0.69-11.67***-0.22
ΔPEF529412.440.190.6310.86***
ΔGCSQ15293-0.26-0.40-0.89-15.24***-0.28
ΔPEF1529316.110.240.8113.86***
Study 2
ΔGCSQ5380-0.20-0.30-0.68-13.40***-0.12
ΔPEF53798.680.150.479.16***
ΔGCSQ15380-0.32-0.48-0.79-15.29***-0.19
ΔPEF1538011.950.210.5510.68***
  • ΔGCSQ5 and δGCSQ15: change in GCSQ score from pre-dose to 5- and 15-min post-dose, respectively. δPEF5 and δPEF15: change in PEF from pre-dose to 5- and 15 min post-dose, respectively. ES: effect size; SRM: standardised response mean. ***: p<0.001.