CDLM | GCSQ | |||
Study 1 | Study 2 | Study 1 | Study 2 | |
Subjects n | 547 | 361 | 646 | 437 |
PEF morning | 0.10* | 0.11* | -0.12* | -0.16* |
FEV1 morning | 0.01 | 0.03 | -0.08 | 0.00 |
Total rescue | -0.37*** | -0.17*** | 0.40*** | 0.20*** |
Breathlessness | -0.65*** | 0.73*** | ||
Cough | -0.43*** | 0.51 | ||
Chest tightness | -0.58*** | 0.81*** | ||
Sleep | -0.56*** | 0.58*** | ||
CCQ | ||||
Total | -0.61*** | 0.70*** | ||
Symptoms | -0.49*** | 0.65*** | ||
Function | -0.63*** | 0.65*** | ||
Mental | -0.53*** | 0.59*** | ||
SGRQ-C | ||||
Total | -0.55*** | -0.49*** | 0.52*** | 0.35*** |
Symptoms | -0.32*** | -0.16*** | 0.42*** | 0.27*** |
Activity | -0.57*** | -0.43*** | 0.44*** | 0.26*** |
Impact | -0.47*** | -0.48*** | 0.46*** | 0.33*** |
PEF: peak expiratory flow; FEV1: forced expiratory volume in 1 s; CCQ: Clinical COPD Questionnaire; SGRQ-C: St George’s Respiratory Questionnaire for COPD patients. *: p<0.05; ***: p<0.001.