UK Healthy (n = 212) | UK and the Netherlands COPD (n = 591) | |||
Regression coefficient (95% CI) | p-value | Regression coefficient (95% CI) | p-value | |
Model constant (QMVC) kg | 56.2 (15.1– 97.4) | 0.008 | 19.6 (0.21–39.1) | 0.048 |
Age yrs | -0.30 (-0.44– -0.16) | <0.001 | -0.31 (-0.38– -0.24) | <0.001 |
Female/male sex | -3.42 (-7.28–0.42) | 0.081 | -2.60 (-4.43– -0.78) | 0.005 |
Height cm | -0.15 (-0.40–0.11) | 0.254 | -2.47 (-13.44–8.49) | 0.657 |
FFM kg | 0.68 (0.45–0.91) | <0.001 | 0.81 (0.68–0.91) | <0.001 |
FEV1 % pred | 0.047 (0.013–0.082) | 0.007 | ||
Model r2 | 0.51 | 0.52 |
Results of multiple linear regression analyses of healthy and COPD patients are shown. Regression coefficients indicate the change in QMVC force per unit change of each covariable indicated. Sex difference represents females compared with males. p-values <0.05 suggest a statistically independent determinant in the regression equation. Sex did not reach the predetermined level of significance when COPD cohorts were analysed separately. FFM: fat-free mass; FEV1: forced expiratory volume in 1 s; % pred; % predicted.