Table 5—

Test characteristics of bronchoscopy and endoscopic ultrasound(E(B)US) for making the diagnosis of sarcoidosis

Diagnoses nDiagnoses % (95% CI)
Yield of bronchoscopy
 Intention to diagnose52/11545 (35–94)
 Per protocol#52/10052 (41–62)
 Per protocol with biopsy52/8462 (50–72)
Yield of E(B)US
 Intention to diagnose45/6371 (58–82)
 Per protocol overall+45/5877 (64–87)
 Per protocol EUS§16/1794 (91–99)
 Per protocol EBUSƒ29/4171 (54–83)
 Per protocol after negative bronchoscopy##33/4377 (61–88)
Yield of bronchoscopy plus E(B)US
 Intention to diagnose97/11584 (76–90)
  • CI: confidence interval; EUS: endoscopic ultrasound; EBUS: endobronchial ultrasound. #: sarcoidosis patients who underwent effective bronchoscopy; : sarcoidosis patients in whom at least one biopsy specimen was taken (endobronchial biopsy (EBB), transbronchial biopsy (TBB), transbronchial needle aspiration (TBNA) or any combination thereof) during bronchoscopy (the relative sensitivities for diagnosis of sarcoidosis were 62% (95% CI 48–74%) for TBB, 24% (14–36%) for EBB and 35% (16–57%) for blind TBNA); +: sarcoidosis patients who underwent effective E(B)US; §: sarcoidosis patients who underwent EUS-guided fine needle aspiration; ƒ: sarcoidosis patients who underwent EBUS-TBNA; ##: sarcoidosis patients who underwent effective bronchoscopy and E(B)US.