Table 3– Total duration of therapy in the study population according to the severity of the disease on admission, after adjusting for regions and process of care indicators

Finding	Total duration of antibiotic therapy days	p-value
PSI risk class		0.2
I	11.0±4.5
II	11.1±4.6
III	10.8±4.6
IV	11.2±4.5
V	11.8±4.6
PSI risk class		0.1
I, II or III	11.1±4.6
IV or V	11.3±4.6
CRB-65 score		0.7
0, 1 or 2	11.2±4.5
3 or 4	11.3±4.5
Altered mental status		0.8
Yes	11.4±4.5
No	11.1±4.5
Admission to ICU		<0.001
Yes	12.3±4.5
No	11.0±4.6
Hypotension^#		0.005
Yes	12.4±4.5
No	11.1±4.5
Acidaemia^¶		0.03
Yes	12.1±4.5
No	11.1±4.6
Alteration of gas exchange⁺		0.2
Yes	11.3±4.6
No	11.1±4.6
Therapy		<0.001
Mono	10.4±4.6
Double	11.5±4.6
Multilobar infiltrate		0.001
Yes	11.7±4.7
No	10.8±4.6
Pleural effusion		0.006
Yes	11.7±4.6
No	11.1±4.6
Congestive heart failure		0.5
Yes	11.0±4.6
No	11.1±4.6
COPD		0.2
Yes	11.3±4.6
No	11.0±4.6
Diabetes mellitus		0.3
Yes	10.9±4.6
No	11.1±4.6
Cerebrovascular accident		0.5
Yes	10.9±4.6
No	11.1±4.7
Liver disease		0.1
Yes	11.9±4.6
No	11.1±4.7
Immunosuppression^§		0.008
Yes	11.8±4.6
No	11.0±4.6

Data are presented as mean±sd, unless otherwise stated. PSI: pneumonia severity index; CRB-65: confusion, respiratory rate ≥30 breaths·min⁻¹, low blood pressure (systolic value <90 mmHg or diastolic value ≤60 mmHg) and age ≥65 yrs; ICU: intensive care unit; COPD: chronic obstructive pulmonary disease. ^#: systolic blood pressure <90 mmHg or diastolic blood pressure <60 mmHg; ^¶: pH <7.35; ⁺: arterial oxygen tension <60 mmHg, arterial oxygen tension/inspiratory oxygen fraction <300 mmHg or oxygen saturation <90%; ^§: cancer, HIV, chronic steroid use.