Gene | SNP | Risk genotype | Noncarriers of risk genotype | Carriers of risk genotype | p-value for interaction# | ||
n | OR (95% CI) | n | OR (95% CI) | ||||
IKZF3 | rs9303277 | CC | 234 | 2.25 (1.35–3.77) | 93 | 4.84 (1.94–12.03) | 0.14 |
ZPBP2 | rs11557467 | GG | 235 | 2.02 (1.20–3.38) | 99 | 5.66 (2.33–13.76) | 0.04 |
Intergenic region | rs8069176 | GG | 214 | 1.74 (1.00–3.01) | 117 | 6.37 (2.78–14.58) | 0.008 |
GSDML (GSDMB) | rs2305480 | GG | 209 | 1.90 (1.11–3.24) | 115 | 6.86 (2.96–15.90) | 0.008 |
GSDML (GSDMB) | rs2305479 | CC | 234 | 2.21 (1.32–3.71) | 101 | 5.65 (2.36–13.52) | 0.06 |
GSDML (GSDMB) | rs4795400 | CC | 211 | 1.85 (1.08–3.17) | 114 | 6.01 (2.59–13.97) | 0.02 |
GSDML (GSDMB) | rs7216389 | TT | 238 | 2.06 (1.25–3.41) | 97 | 7.16 (2.78–18.44) | 0.02 |
GSDML (GSDMB) | rs9303281 | AA | 236 | 2.17 (1.31–3.62) | 94 | 6.03 (2.39–15.21) | 0.05 |
GSDML (GSDMB) | rs7219923 | TT | 219 | 2.09 (1.25–3.51) | 110 | 6.65 (2.52–17.51) | 0.03 |
ORMDL3 | rs8076131 | AA | 218 | 2.01 (1.19–3.38) | 111 | 6.12 (2.58–14.50) | 0.02 |
Intergenic region | rs4795405 | CC | 214 | 1.99 (1.18–3.38) | 118 | 5.63 (2.39–13.30) | 0.04 |
Intergenic region | rs4794820 | GG | 238 | 2.24 (1.31–3.80) | 92 | 5.74 (2.54–13.00) | 0.05 |
SNP: single nucleotide polymorphisms. #: p-values for association of remittent asthma and infection ranged between 0.05×10−3 and 2.2×10−3 in subjects with the nonrisk genotype and between 8.0×10−4 and 1.3×10−5 in subjects with the risk genotype. The p-values for interaction that were <0.05 in this table still reached that significance level when they were obtained by simulations, except for rs9303281 and rs4794820 (p = 0.06). Bold values indicate significance.