Table 3– Association of early-onset asthma and early respiratory infection in children, according to 17q21 SNPs
GeneSNPRisk genotypeNoncarriers of risk genotypeCarriers of risk genotypep-value for interaction#
nOR (95% CI)nOR (95% CI)
IKZF3rs9303277CC2562.44 (1.47–4.07)1273.42 (1.59–7.39)0.46
ZPBP2rs11557467GG2592.35 (1.41–3.90)1294.08 (1.91–8.73)0.22
Intergenic regionrs8069176GG2341.84 (1.06–3.20)1525.24 (2.53–10.83)0.02
GSDML (GSDMB)rs2305480GG2321.89 (1.11–3.22)1515.50 (2.66–11.38)0.02
GSDML (GSDMB)rs2305479CC2602.28 (1.38–3.77)1344.15 (1.97–8.76)0.17
GSDML (GSDMB)rs4795400CC2321.90 (1.10–3.28)1484.73 (2.32–9.65)0.04
GSDML (GSDMB)rs7216389TT2642.15 (1.30–3.53)1196.36 (2.72–14.86)0.02
GSDML (GSDMB)rs9303281AA2672.24 (1.36–3.68)1254.22 (1.97–9.05)0.16
GSDML (GSDMB)rs7219923TT2632.15 (1.29–3.57)1204.81 (2.13–10.87)0.08
ORMDL3rs8076131AA2442.01 (1.20–3.36)1434.95 (2.37–10.35)0.04
Intergenic regionrs4795405CC2392.07 (1.21–3.54)1454.68 (2.30–9.54)0.07
Intergenic regionrs4794820GG2342.36 (1.38–4.01)1494.49 (2.23–9.04)0.14
  • SNP: single nucleotide polymorphisms. #: p-values for association of early-onset asthma and infection ranged between 0.03×10−4 and 7.5×10−4 in subjects with the nonrisk genotype and between 1.4×10−3 and 4.6×10−6 in subjects with the risk genotype. The p-values for interaction that were <0.05 in this table still reached that significance level when they were obtained by simulations, except for rs8076131 (p = 0.06). Bold values indicate significance.