Fibrosis | No fibrosis | p-value | |
Subjects n | 13 | 20 | |
Age yrs | 57 | 60 | ns |
Female | 4 (31) | 13 (65) | ns |
Male | 9 (69) | 7 (35) | ns |
Renal manifestations | 13 (100) | 20 (100) | ns |
Fever | 8 (61) | 19 (95) | 0.02 |
Fatigue | 4 (31) | 8 (40) | ns |
Weight loss | 1 (8) | 2 (10) | ns |
Arthralgias | 4 (31) | 4 (20) | ns |
Myalgias | 6 (46) | 1 (5) | 0.008 |
Skin involvement | 1 (8) | 3 (15) | ns |
GI involvement | 1 (8) | 0 (0) | ns |
Peripheral nervous system | 1 (8) | 3 (15) | ns |
Haemoptysis | 5 (38) | 4 (20) | ns |
Dyspnoea | 4 (31) | 0 (0) | 0.01 |
Chronic cough | 3 (23) | 0 (0) | ns |
Laboratory | |||
P-ANCA | 11 (85) | 20 (100) | ns |
P-ANCA and C-ANCA | 1 (8) | ||
Radiological CT | |||
Ground-glass opacities | 3 (23) | 8 (40) | ns |
Reticular pattern | 10 (77) | 2 (10) | 0.002 |
Bronchiectasis | 5 (38) | 2 (10) | ns |
Interlobular septal thickening | 9 (69) | 0 (0) | 0.0001 |
Honeycombing | 6 (46) | 0 (0) | 0.001 |
Airspace consolidation | 0 (0) | 2 (10) | ns |
Thin-walled parenchymal cysts | 2 (15) | 0 (0) | ns |
Pleural thickening | 3 (23) | 0 (0) | ns |
CT pattern of fibrosis | |||
UIP | 7 (54) | ||
NSIP | 4 (31) |
Data are presented as n absolute patients (% of group analysed), unless otherwise stated. GI: gastrointestinal; P-ANCA: perinuclear anti-neutrophilic cytoplasmic antibody; C-ANCA: cytoplamsic anti-neutrophilic cytoplasmic antibody CT: computerised tomography; UIP: usual interstitial pneumonia; NSIP: nonspecific interstitial pneumonia; ns: nonsignificant.